{"id":"W1976146981","doi":"10.1039/c5ay00523j","title":"Site-selective characterization of Src homology 3 domain molecular recognition with cyanophenylalanine infrared probes","year":2015,"lang":"en","type":"article","venue":"Analytical Methods","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; National Institutes of Health; University of Toronto","keywords":"Homology (biology); Infrared; Characterization (materials science); Molecular recognition; Chemistry; Computational biology; Materials science; Nanotechnology; Biology; Physics; Biochemistry; Molecule; Gene; Optics; Organic chemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000316583,0.0003126409,0.0001871844,0.000135618,0.0001591462,0.0001768943,0.0003889772,0.0003097119,0.000794777],"category_scores_gemma":[0.0002931891,0.0001452927,0.0001903238,0.0001172404,0.0002707999,0.0002247337,0.0001779816,0.0005301923,0.0002767831],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002504049,"about_ca_system_score_gemma":0.0001489861,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004049701,"about_ca_topic_score_gemma":0.0006002972,"domain_scores_codex":[0.9998105,0.0000326446,0.000006300792,0.00004521272,0.00006344481,0.00004193965],"domain_scores_gemma":[0.999828,0.00006468728,0.00004522947,0.00001617569,0.0000235046,0.00002252681],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001893801,0.000003875344,0.00002925959,0.00001023126,0.000001003963,0.000009923587,0.000006309362,0.00003966581,0.9993674,0.00004225583,0.00001335218,0.0004577909],"study_design_scores_gemma":[0.000002360258,0.00003579765,0.0003437622,5.441109e-7,0.000001767599,0.00003888667,0.000003495167,0.0005311972,0.9987759,0.00001333927,0.0002510319,0.000001909795],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9484798,0.0006064567,0.04853704,0.0001136475,0.00001965072,0.00003088827,0.0001768536,0.0001633402,0.001872224],"genre_scores_gemma":[0.9742295,0.0005157444,0.02311768,0.00007620358,0.00001442632,0.00006749557,0.0002851984,0.00004869379,0.001645066],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000794777,"threshold_uncertainty_score":0.002658784,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02092847445952917,"score_gpt":0.3049660715759857,"score_spread":0.2840375971164565,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}