{"id":"W1976150153","doi":"10.1073/pnas.0913089107","title":"Caspase 3/caspase-activated DNase promote cell differentiation by inducing DNA strand breaks","year":2010,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":242,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Ontario Ministry of Research and Innovation; Canadian Institutes of Health Research; Muscular Dystrophy Association","keywords":"Cell biology; Biology; Caspase 2; Chromatin; Caspase; Cellular differentiation; Nuclease; Molecular biology; DNA; Apoptosis; Programmed cell death; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002228783,0.0003652335,0.0002272201,0.0002310819,0.0001433845,0.0003244554,0.0001530614,0.0003718357,0.00306183],"category_scores_gemma":[0.0001772131,0.0001317928,0.0003578194,0.0001095551,0.0003039426,0.0003016611,0.0002411679,0.0007976981,0.0006751029],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003427395,"about_ca_system_score_gemma":0.0002804221,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002059579,"about_ca_topic_score_gemma":0.0005379964,"domain_scores_codex":[0.999846,0.00002707789,0.00001335758,0.0000272035,0.00004895777,0.00003743312],"domain_scores_gemma":[0.9998189,0.00004346095,0.00004480729,0.00002160017,0.00002005956,0.0000512398],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005222584,0.00001776932,0.0001308593,0.00002596402,0.000003229045,0.00002684702,0.00000651429,0.00002390567,0.998737,0.0001186466,0.00001795315,0.0008389944],"study_design_scores_gemma":[0.00001635081,0.0001132333,0.001487185,0.000004396273,0.000004877661,0.000147135,0.00001012901,0.0002785446,0.9967113,0.0000802741,0.001144965,0.000001582782],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9805531,0.00424396,0.01105412,0.0002041429,0.00005405592,0.00005154772,0.0002836658,0.0001526333,0.003402886],"genre_scores_gemma":[0.9861779,0.001413008,0.007691429,0.00007134836,0.00001216142,0.0000252946,0.0003656874,0.00001732387,0.0042259],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00306183,"threshold_uncertainty_score":0.01024282,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01315833660586994,"score_gpt":0.2534365623817525,"score_spread":0.2402782257758826,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}