{"id":"W1976150153","doi":"10.1073/pnas.0913089107","title":"Caspase 3/caspase-activated DNase promote cell differentiation by inducing DNA strand breaks","year":2010,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":242,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Ontario Ministry of Research and Innovation; Canadian Institutes of Health Research; Muscular Dystrophy Association","keywords":"Cell biology; Biology; Caspase 2; Chromatin; Caspase; Cellular differentiation; Nuclease; Molecular biology; DNA; Apoptosis; Programmed cell death; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004410739,0.00009153032,0.00008685233,0.00005817528,0.0001578196,0.00002308236,0.0002827252,0.0001596506,0.0000131458],"category_scores_gemma":[0.00009751649,0.00006352776,0.00005550725,0.0002035026,0.0002102333,0.00002793735,0.00007068776,0.0001333033,3.207428e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000654874,"about_ca_system_score_gemma":0.00002529261,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009154749,"about_ca_topic_score_gemma":3.732117e-7,"domain_scores_codex":[0.9989897,0.000004722941,0.0002027311,0.0002375767,0.0004474054,0.0001178649],"domain_scores_gemma":[0.9994656,0.00001021088,0.000306334,0.00001177394,0.0001682951,0.00003772223],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001432294,0.00005309775,0.0002871375,0.00002491065,0.00000671401,2.659095e-9,0.00003726631,0.0000135791,0.9980026,0.0006990996,0.0003043813,0.0005569187],"study_design_scores_gemma":[0.0002316243,0.00005650217,0.006939984,0.00001571847,0.000009937268,0.000004646507,0.00003092108,0.0005338859,0.9898909,0.001920812,0.0002863558,0.00007866445],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984682,0.00004141911,0.00001020439,0.0004348008,0.00003555524,0.0001644121,0.00002413197,0.000004666877,0.0008166105],"genre_scores_gemma":[0.9991004,0.00001451863,0.0004353588,0.00005202723,0.00008587242,0.000005380312,0.000004745611,0.000005262217,0.0002963766],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008111621,"threshold_uncertainty_score":0.2590587,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01315833660586994,"score_gpt":0.2534365623817525,"score_spread":0.2402782257758826,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}