{"id":"W1976158989","doi":"10.1182/blood-2010-06-288001","title":"Eradication of neutralizing antibodies to factor VIII in canine hemophilia A after liver gene therapy","year":2010,"lang":"en","type":"article","venue":"Blood","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":156,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; U.S. Public Health Service; National Institutes of Health","keywords":"Medicine; Antibody; Clotting factor; Genetic enhancement; Factor IX; Titer; Antigen; Immunology; Internal medicine; Gastroenterology; Gene; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002200023,0.0002141904,0.0003720692,0.0003123578,0.0001557783,0.0002868073,0.000193143,0.0003582209,0.0005211875],"category_scores_gemma":[0.0002864357,0.0001178152,0.0002224501,0.0001337288,0.0004057882,0.0002587672,0.0001426108,0.0004788362,0.0001463312],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004279147,"about_ca_system_score_gemma":0.0001695004,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001156551,"about_ca_topic_score_gemma":0.0009665092,"domain_scores_codex":[0.9998642,0.00002611614,0.000007242424,0.00002439844,0.00003376767,0.00004429082],"domain_scores_gemma":[0.9998697,0.0000344659,0.00003385896,0.00001315118,0.00001482571,0.0000340541],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006932393,0.0003635317,0.001207304,0.00005511287,0.00001351246,0.0002982313,0.00007620837,0.0002668473,0.9895836,0.0003430166,0.0002137308,0.006885536],"study_design_scores_gemma":[0.0003862735,0.0158332,0.02300814,0.00001861506,0.0000987642,0.004843341,0.00009825388,0.005950546,0.9406046,0.0004395481,0.008693388,0.00002540454],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973695,0.0005694311,0.00124373,0.00006534174,0.00001559495,0.00002829272,0.00004083293,0.00004531877,0.000621888],"genre_scores_gemma":[0.9976779,0.0003223607,0.0006714531,0.00003775071,0.000009798538,0.000027681,0.000149767,0.00001349327,0.001089935],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001156551,"threshold_uncertainty_score":0.003104746,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01550498052386678,"score_gpt":0.2841528228913235,"score_spread":0.2686478423674568,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}