{"id":"W1976181134","doi":"10.1016/j.bone.2011.04.001","title":"Denosumab, a fully human RANKL antibody, reduced bone turnover markers and increased trabecular and cortical bone mass, density, and strength in ovariectomized cynomolgus monkeys","year":2011,"lang":"en","type":"article","venue":"Bone","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":98,"is_retracted":false,"has_abstract":false,"ca_institutions":"TransCanada (Canada)","funders":"Amgen","keywords":"Denosumab; Osteoclast; Ovariectomized rat; Bone remodeling; Endocrinology; Internal medicine; Osteoporosis; Bone mineral; RANKL; Bone resorption; Medicine; Femoral neck; Bone density; Cancellous bone; Urology; Anatomy; Receptor; Estrogen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003012844,0.0003227154,0.0005362441,0.0001168859,0.000130322,0.0000587551,0.00007856073,0.0002443314,0.00004423313],"category_scores_gemma":[0.0001811444,0.0003136904,0.00008033615,0.0001059807,0.0003686808,0.00001730202,0.0001984772,0.0001686809,0.000001900957],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009303054,"about_ca_system_score_gemma":0.00007196368,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008244428,"about_ca_topic_score_gemma":0.0002731853,"domain_scores_codex":[0.9981661,0.0001943637,0.0004106907,0.000652287,0.0001742489,0.0004023525],"domain_scores_gemma":[0.999104,0.00002824147,0.0001114394,0.0003655382,0.00005513956,0.0003355908],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00269882,0.0003005045,0.05490302,0.00006666321,0.00009833636,0.0002863304,0.0001100243,1.051556e-7,0.9401836,0.0002898885,0.000209715,0.0008529539],"study_design_scores_gemma":[0.01227721,0.0003303714,0.8939843,0.00005273852,0.000312979,0.0002365258,0.0001104782,0.00005592475,0.09100399,0.0006974968,0.0003239753,0.0006140731],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911461,0.007876066,0.00008573225,0.00004215806,0.00004691277,0.0003578924,0.00003896679,0.00002103285,0.0003851566],"genre_scores_gemma":[0.9975895,0.000682154,0.001232955,0.0001293081,0.00007174904,0.0000204431,0.0001335612,0.00003710664,0.000103185],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8491796,"threshold_uncertainty_score":0.9999315,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009291874422518501,"score_gpt":0.2329218021522652,"score_spread":0.2236299277297467,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}