{"id":"W1976181134","doi":"10.1016/j.bone.2011.04.001","title":"Denosumab, a fully human RANKL antibody, reduced bone turnover markers and increased trabecular and cortical bone mass, density, and strength in ovariectomized cynomolgus monkeys","year":2011,"lang":"en","type":"article","venue":"Bone","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":98,"is_retracted":false,"has_abstract":false,"ca_institutions":"TransCanada (Canada)","funders":"Amgen","keywords":"Denosumab; Osteoclast; Ovariectomized rat; Bone remodeling; Endocrinology; Internal medicine; Osteoporosis; Bone mineral; RANKL; Bone resorption; Medicine; Femoral neck; Bone density; Cancellous bone; Urology; Anatomy; Receptor; Estrogen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001521495,0.0004446516,0.0005649339,0.0007070323,0.0003540205,0.0003924765,0.0002342122,0.0004545579,0.001192583],"category_scores_gemma":[0.0001864363,0.0003921474,0.0002546602,0.0002164037,0.0005569968,0.0001887103,0.0001729414,0.0008669908,0.0003055012],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004405424,"about_ca_system_score_gemma":0.0003778833,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004078287,"about_ca_topic_score_gemma":0.007476189,"domain_scores_codex":[0.9997978,0.0000341842,0.00001149005,0.00003350605,0.00004642578,0.00007664435],"domain_scores_gemma":[0.9998796,0.00001482072,0.00004006139,0.0000139346,0.00001054124,0.00004113033],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002749236,0.0001813894,0.0004455165,0.00003630242,0.00002612985,0.00009491866,0.00003551895,0.0000626261,0.9936545,0.00009135815,0.0001590181,0.002463441],"study_design_scores_gemma":[0.001385924,0.01057799,0.03342,0.00003033392,0.0003755671,0.001133805,0.0002418028,0.001912058,0.9430224,0.0004863217,0.00736902,0.00004474013],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959738,0.002014656,0.0004043773,0.0003012405,0.00003919813,0.0000195538,0.0003024043,0.00007844716,0.0008663816],"genre_scores_gemma":[0.9921692,0.001546558,0.000605105,0.0002023994,0.0000361924,0.00006012939,0.0004451595,0.00003083046,0.004904417],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004078287,"threshold_uncertainty_score":0.008109093,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009291874422518501,"score_gpt":0.2329218021522652,"score_spread":0.2236299277297467,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}