{"id":"W1976199077","doi":"10.1093/nar/gni051","title":"Conditional and inducible transgene expression in mice through the combinatorial use of Cre-mediated recombination and tetracycline induction","year":2005,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":391,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute","funders":"National Cancer Institute; Canadian Institutes of Health Research","keywords":"Biology; Transgene; Cre recombinase; Genetically modified mouse; Recombinase; Gene; Embryonic stem cell; Gene expression; Transactivation; Gene targeting; Molecular biology; Cell biology; Regulation of gene expression; Genetics; Recombination","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001154624,0.0001087047,0.0001309344,0.0001528872,0.0001656714,0.00004299208,0.000167932,0.0002297687,0.00006416253],"category_scores_gemma":[0.0003888493,0.00008890322,0.00002577544,0.0003339741,0.0004263275,0.00004351798,0.0001149258,0.0004351179,0.000004796388],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003712705,"about_ca_system_score_gemma":0.000103759,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006213404,"about_ca_topic_score_gemma":0.0001124398,"domain_scores_codex":[0.998118,0.0005110757,0.0002552255,0.000349671,0.000479241,0.000286741],"domain_scores_gemma":[0.9992071,0.0001817811,0.00004939975,0.0002404766,0.0002543544,0.00006683272],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001415656,0.0002091314,0.001664265,0.00001792087,0.00001735226,9.219668e-7,0.000312354,0.00004068813,0.989481,0.0001467841,0.0006231364,0.006070754],"study_design_scores_gemma":[0.002615192,0.001627138,0.0119142,0.0000308176,0.000003731285,0.000008295393,0.0002394805,0.0003126357,0.9702636,0.001326509,0.01152951,0.0001288893],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974464,0.0005646475,0.00004590908,0.001303992,0.00005402501,0.000406494,0.00003120073,0.000005071372,0.0001422845],"genre_scores_gemma":[0.997849,0.001264899,0.0003287927,0.00005931854,0.000173671,0.00004094583,0.00014218,0.0000208014,0.0001203786],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01921744,"threshold_uncertainty_score":0.3625368,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0625401003465286,"score_gpt":0.3606837535678538,"score_spread":0.2981436532213252,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}