{"id":"W1976200263","doi":"10.1016/j.pain.2007.11.008","title":"Alvimopan, a peripherally acting mu-opioid receptor (PAM-OR) antagonist for the treatment of opioid-induced bowel dysfunction: Results from a randomized, double-blind, placebo-controlled, dose-finding study in subjects taking opioids for chronic non-cancer pain","year":2008,"lang":"en","type":"article","venue":"Pain","topic":"Gastrointestinal motility and disorders","field":"Medicine","cited_by":144,"is_retracted":false,"has_abstract":true,"ca_institutions":"Manna Research","funders":"","keywords":"Double blind; Medicine; Placebo; Opioid antagonist; Antagonist; Opioid; Randomized controlled trial; Anesthesia; Receptor antagonist; Opioid receptor; Internal medicine; Pharmacology; Receptor; (+)-Naloxone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.007766675,0.000561298,0.001787454,0.0002302136,0.0005906529,0.00006480441,0.0002312911,0.0001664788,0.00009308655],"category_scores_gemma":[0.005765323,0.000369297,0.000671836,0.0003803723,0.0001658375,0.0001345251,0.00003228891,0.0002894042,0.000002575405],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008460283,"about_ca_system_score_gemma":0.000931568,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00623579,"about_ca_topic_score_gemma":0.006925075,"domain_scores_codex":[0.9955064,0.0010357,0.001423959,0.0008478041,0.0004318389,0.0007542869],"domain_scores_gemma":[0.984602,0.01360837,0.0008412321,0.0005654223,0.000221894,0.0001611289],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9382682,0.001914269,0.01717572,0.0002650516,0.0008444163,0.00002687187,0.01302316,0.0005130467,0.002782291,0.000004253938,0.0001658155,0.02501694],"study_design_scores_gemma":[0.9256314,0.00751936,0.004488221,0.0007857669,0.0007054461,0.000008286488,0.01117125,0.0477709,0.001046777,0.00002238785,0.0005022826,0.0003479145],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9572506,0.001063007,0.01822739,0.001242558,0.0005685701,0.02136442,0.00008343357,0.00008266146,0.0001173543],"genre_scores_gemma":[0.9868855,0.0003643734,0.002370416,0.0001825526,0.000797681,0.00866241,0.000129052,0.00007585803,0.0005321736],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04725785,"threshold_uncertainty_score":0.9998759,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07226409688141952,"score_gpt":0.3295272143733022,"score_spread":0.2572631174918827,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}