{"id":"W1976200263","doi":"10.1016/j.pain.2007.11.008","title":"Alvimopan, a peripherally acting mu-opioid receptor (PAM-OR) antagonist for the treatment of opioid-induced bowel dysfunction: Results from a randomized, double-blind, placebo-controlled, dose-finding study in subjects taking opioids for chronic non-cancer pain","year":2008,"lang":"en","type":"article","venue":"Pain","topic":"Gastrointestinal motility and disorders","field":"Medicine","cited_by":144,"is_retracted":false,"has_abstract":true,"ca_institutions":"Manna Research","funders":"","keywords":"Double blind; Medicine; Placebo; Opioid antagonist; Antagonist; Opioid; Randomized controlled trial; Anesthesia; Receptor antagonist; Opioid receptor; Internal medicine; Pharmacology; Receptor; (+)-Naloxone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002129878,0.0009117454,0.003385226,0.000485859,0.000380298,0.0005227966,0.0009047648,0.001355465,0.003115389],"category_scores_gemma":[0.001780112,0.0005957693,0.001383181,0.000498736,0.0009661603,0.0007780534,0.000298627,0.001490412,0.0004107943],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002736726,"about_ca_system_score_gemma":0.0005728842,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003998766,"about_ca_topic_score_gemma":0.001075901,"domain_scores_codex":[0.9991528,0.0004934496,0.00009390082,0.0001036458,0.00007615039,0.00008021062],"domain_scores_gemma":[0.9985597,0.0005511047,0.0003466854,0.0000866339,0.0001010947,0.0003549172],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9174204,0.01440331,0.001360517,0.001693805,0.00126423,0.00008287205,0.00007979873,0.0002207137,0.02542916,0.00005070613,0.0003472632,0.03764718],"study_design_scores_gemma":[0.6750711,0.307591,0.01217361,0.00005222428,0.001248705,0.000116943,0.0000405914,0.0002742757,0.002667665,0.00004834748,0.000690578,0.00002500413],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9869626,0.008448621,0.000853898,0.0002007479,0.0001483505,0.00189942,0.0005112367,0.0000897901,0.00088527],"genre_scores_gemma":[0.9866224,0.006676348,0.002231366,0.0005478958,0.0003697643,0.001663312,0.0008196076,0.0000224509,0.00104683],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003385226,"threshold_uncertainty_score":0.01126403,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07226409688141952,"score_gpt":0.3295272143733022,"score_spread":0.2572631174918827,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}