{"id":"W1976209099","doi":"10.1007/s11095-013-1259-1","title":"Current Challenges in Bioequivalence, Quality, and Novel Assessment Technologies for Topical Products","year":2014,"lang":"en","type":"review","venue":"Pharmaceutical Research","topic":"Transgenic Plants and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":87,"is_retracted":false,"has_abstract":false,"ca_institutions":"FSD Pharma (Canada)","funders":"American Association of Pharmaceutical Scientists","keywords":"Bioequivalence; Pharmaceutical industry; Risk analysis (engineering); Quality (philosophy); Quality by Design; Management science; Regulatory science; Product (mathematics); Computer science; Medicine; New product development; Business; Pharmacology; Engineering; Bioavailability; Marketing","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003241207,0.0008566378,0.002053122,0.001821678,0.0003481383,0.002183865,0.001435393,0.002187007,0.003326188],"category_scores_gemma":[0.002223975,0.0003982208,0.0007806341,0.002204259,0.001234056,0.002909,0.001016201,0.002533322,0.001235618],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001009416,"about_ca_system_score_gemma":0.002167757,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001650662,"about_ca_topic_score_gemma":0.002503898,"domain_scores_codex":[0.9990319,0.0001618001,0.0001021594,0.0001708356,0.0004688523,0.00006437077],"domain_scores_gemma":[0.9977278,0.001456389,0.0002366727,0.00006424279,0.0004423534,0.00007256532],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009739881,0.0001071548,0.0002528531,0.01253907,0.00006266777,0.0001763925,0.00006354268,0.0006043155,0.0067517,0.009348672,0.011228,0.9587682],"study_design_scores_gemma":[0.00002479952,0.0002422512,0.001029823,0.003513548,0.0001792921,0.00144237,0.0001900998,0.0004779997,0.004712643,0.008221699,0.9799163,0.00004918445],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003383672,0.9965239,0.001089378,0.0007543959,0.0001338323,0.000007101782,0.0000244007,0.00001133801,0.001117205],"genre_scores_gemma":[0.002450961,0.9944484,0.001456425,0.0005038671,0.0002314893,0.00001166241,0.00004371962,0.000004613792,0.0008488568],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003326188,"threshold_uncertainty_score":0.01714134,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.7074066587856508,"score_gpt":0.6422555944921446,"score_spread":0.06515106429350614,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}