{"id":"W1976211868","doi":"10.1016/j.bmcl.2010.07.070","title":"Synthesis of MRI contrast agents derived from DOTAM-Gly-l-Phe-OH incorporating a disulfide bridge: Conjugation to a cell penetrating peptide and preparation of a dimeric agent","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Lanthanide and Transition Metal Complexes","field":"Materials Science","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"","keywords":"Chemistry; Conjugate; Peptide; Disulfide bond; Combinatorial chemistry; Iodine; Cyclic peptide; Stereochemistry; Organic chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002687282,0.000411528,0.0004229739,0.0001689982,0.0002105542,0.000238884,0.0002932095,0.0003699749,0.0007567014],"category_scores_gemma":[0.0002398425,0.0003105889,0.0002274967,0.0001892962,0.0001712295,0.0002929385,0.0002645509,0.0005729574,0.0005453606],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002268629,"about_ca_system_score_gemma":0.0002171813,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001804504,"about_ca_topic_score_gemma":0.0003002328,"domain_scores_codex":[0.9999112,0.00001447441,0.00001237674,0.00002200419,0.00001797175,0.00002189463],"domain_scores_gemma":[0.9998858,0.00001644164,0.00002919946,0.00001591539,0.00001948064,0.00003322047],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004882285,0.00002423826,0.00002796274,0.00003962666,0.000004593388,0.00005007287,0.00001843519,0.00008610733,0.9980439,0.0001684551,0.00004446643,0.001443232],"study_design_scores_gemma":[0.00001175881,0.00007336294,0.0000882078,0.000001569599,0.000006844673,0.00007061296,0.000002850339,0.0002336856,0.9977751,0.0000182238,0.001715112,0.000002581989],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9436526,0.003004468,0.04813905,0.0002679439,0.0001165573,0.0004018882,0.0005210824,0.0002445861,0.003651864],"genre_scores_gemma":[0.9375128,0.001648937,0.05318614,0.0002086057,0.00003714381,0.0002330532,0.0009574984,0.0001123034,0.006103613],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007567014,"threshold_uncertainty_score":0.002531469,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01234880193545597,"score_gpt":0.2413505007693382,"score_spread":0.2290016988338822,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}