{"id":"W1976234805","doi":"10.1016/s0005-2736(01)00294-2","title":"Programmable fusogenic vesicles for intracellular delivery of antisense oligodeoxynucleotides: enhanced cellular uptake and biological effects","year":2001,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - Biomembranes","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":false,"ca_institutions":"Inimex Pharmaceuticals (Canada); BC Cancer Agency; University of British Columbia","funders":"National Cancer Institute","keywords":"Intracellular; Liposome; Vesicle; Ceramide; Biophysics; Chemistry; Molecular biology; Flow cytometry; PEG ratio; In vitro; Cell culture; Transfection; Biology; Biochemistry; Apoptosis; Membrane","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002037766,0.0003021899,0.0002635794,0.0001526149,0.0001515458,0.0004463303,0.0002190839,0.0003456632,0.0003242572],"category_scores_gemma":[0.0001778947,0.0001499886,0.0002107229,0.0001579291,0.0001973509,0.0003877763,0.0003051263,0.0002991494,0.0001581395],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004894282,"about_ca_system_score_gemma":0.0001802171,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005289178,"about_ca_topic_score_gemma":0.0007021242,"domain_scores_codex":[0.9999084,0.00001264827,0.000007341046,0.0000198822,0.00002778936,0.00002386597],"domain_scores_gemma":[0.999933,0.00001487643,0.00002144962,0.000009189082,0.00001046117,0.00001102141],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006326501,0.000005898193,0.00004178377,0.00002640661,0.000003694968,0.00003569377,0.00001923837,0.0001537911,0.9975222,0.0005141416,0.00002131356,0.001592682],"study_design_scores_gemma":[0.000005992177,0.00003934444,0.0001622577,0.000002137119,0.000006973316,0.00006904183,0.000007150375,0.0006544886,0.9979033,0.00005196453,0.001093366,0.00000400085],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9657103,0.002130773,0.03008941,0.00007644454,0.00004029593,0.00006051553,0.0002322996,0.00023407,0.001425858],"genre_scores_gemma":[0.9898606,0.0008820393,0.00744642,0.00002940708,0.000005229384,0.00003885861,0.000127712,0.00005385382,0.001555926],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005289178,"threshold_uncertainty_score":0.003551066,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01367595035963272,"score_gpt":0.2422406366380937,"score_spread":0.228564686278461,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}