{"id":"W1976243978","doi":"10.1002/acn3.148","title":"Efficacy of delayed‐release dimethyl fumarate in relapsing‐remitting multiple sclerosis: integrated analysis of the phase 3 trials","year":2014,"lang":"en","type":"article","venue":"Annals of Clinical and Translational Neurology","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"NeuroRx Research (Canada); McGill University; Montreal Neurological Institute and Hospital","funders":"Sanofi Genzyme; Chugai Pharmaceutical; EMD Serono; Genentech; Sanofi; Bayer HealthCare; University College London Hospitals NHS Foundation Trust; Acorda Therapeutics; Eli Lilly and Company; Health Research Board; GlaxoSmithKline; Biogen; National Institute for Health and Care Research; Teva Pharmaceutical Industries","keywords":"Medicine; Dimethyl fumarate; Placebo; Multiple sclerosis; Internal medicine; Cohort; Population; Gastroenterology; Phases of clinical research; Clinical trial; Pathology; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02559622,0.001198435,0.004285503,0.001041095,0.0002771592,0.001309504,0.0007129479,0.0008982414,0.00162205],"category_scores_gemma":[0.01793675,0.0004473781,0.006206754,0.001317293,0.0003353041,0.0008284327,0.00079485,0.00121467,0.0001506967],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000892133,"about_ca_system_score_gemma":0.00166997,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001026708,"about_ca_topic_score_gemma":0.002406443,"domain_scores_codex":[0.9862117,0.01088978,0.0006571925,0.0007107497,0.001145251,0.0003853675],"domain_scores_gemma":[0.9873108,0.006133321,0.004344496,0.0007978571,0.0009310236,0.0004825503],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.7032944,0.001887172,0.04398157,0.007075548,0.1078318,0.00009144667,0.0001870787,0.004202609,0.007950595,0.0004171628,0.001645417,0.1214353],"study_design_scores_gemma":[0.4277716,0.150098,0.2899258,0.001916255,0.107724,0.0003546395,0.0001553896,0.005593316,0.004918988,0.001020774,0.01037973,0.0001414563],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.879993,0.09450342,0.007939406,0.0008329619,0.0001706885,0.007821267,0.00611824,0.0002166258,0.002404379],"genre_scores_gemma":[0.9761415,0.008436327,0.006921116,0.0006012155,0.0001779819,0.003733817,0.003428317,0.00005388842,0.0005057554],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02559622,"threshold_uncertainty_score":0.1353673,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3466909335908953,"score_gpt":0.4765103266234633,"score_spread":0.129819393032568,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}