{"id":"W1976257390","doi":"10.1172/jci44564","title":"Estrogen receptor activation reduces lipid synthesis in pancreatic islets and prevents β cell failure in rodent models of type 2 diabetes","year":2011,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":180,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"NHLBI Division of Intramural Research; Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Environmental Health Sciences; Canadian Institutes of Health Research; Feinberg School of Medicine; U.S. Department of Agriculture; Canadian Diabetes Association; National Cancer Institute; National Institutes of Health; March of Dimes Foundation; Northwestern University; Juvenile Diabetes Research Foundation International","keywords":"Endocrinology; Internal medicine; Lipid metabolism; Glucose homeostasis; Estrogen receptor; Biology; Pancreatic islets; Insulin; Estrogen; Insulin resistance; Type 2 diabetes; Islet; Pancreas; Diabetes mellitus; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003268253,0.0007058561,0.0007051267,0.0007530858,0.0002098561,0.0003584194,0.0003834883,0.0005237632,0.001430083],"category_scores_gemma":[0.0002262606,0.0003520046,0.000432642,0.0004054456,0.0003562735,0.0002903332,0.000236882,0.001293861,0.0003309065],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002970245,"about_ca_system_score_gemma":0.0003933578,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007032847,"about_ca_topic_score_gemma":0.001576873,"domain_scores_codex":[0.9997832,0.00003544726,0.000031211,0.00003789815,0.00005598292,0.00005620584],"domain_scores_gemma":[0.9997812,0.00001910176,0.00006650159,0.00003463207,0.00001811899,0.00008052243],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001879357,0.0004946992,0.0004628204,0.0001187099,0.00003938177,0.00007978137,0.00002916397,0.0001620057,0.9911131,0.0001433272,0.0001999289,0.005277776],"study_design_scores_gemma":[0.000650169,0.007606903,0.01103688,0.00005898011,0.0001679929,0.0004143776,0.000135555,0.0007263536,0.971516,0.0002385512,0.007419232,0.00002890275],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894014,0.004192682,0.002949041,0.0003140361,0.0002036212,0.00008532702,0.0008753008,0.0003997647,0.001578815],"genre_scores_gemma":[0.9789776,0.007518532,0.003989305,0.0003188549,0.00006637853,0.0002298887,0.00170174,0.0001177929,0.00707991],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001430083,"threshold_uncertainty_score":0.004784167,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08489625709867195,"score_gpt":0.3146943365462345,"score_spread":0.2297980794475626,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}