{"id":"W1976257390","doi":"10.1172/jci44564","title":"Estrogen receptor activation reduces lipid synthesis in pancreatic islets and prevents β cell failure in rodent models of type 2 diabetes","year":2011,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":180,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"NHLBI Division of Intramural Research; Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Environmental Health Sciences; Canadian Institutes of Health Research; Feinberg School of Medicine; U.S. Department of Agriculture; Canadian Diabetes Association; National Cancer Institute; National Institutes of Health; March of Dimes Foundation; Northwestern University; Juvenile Diabetes Research Foundation International","keywords":"Endocrinology; Internal medicine; Lipid metabolism; Glucose homeostasis; Estrogen receptor; Biology; Pancreatic islets; Insulin; Estrogen; Insulin resistance; Type 2 diabetes; Islet; Pancreas; Diabetes mellitus; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001293605,0.0000993614,0.0005610962,0.0002153753,0.0000112114,0.000006348826,0.00005730664,0.0001493304,0.00005954325],"category_scores_gemma":[0.003141654,0.00007917591,0.00008073331,0.000225936,0.0001010424,0.0003112778,0.00001469358,0.0002536967,0.000002512192],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003679885,"about_ca_system_score_gemma":0.0001743022,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002321473,"about_ca_topic_score_gemma":0.000001493957,"domain_scores_codex":[0.998024,0.0002567827,0.001238664,0.0001318664,0.0002337584,0.0001148897],"domain_scores_gemma":[0.9981595,0.0006405547,0.0007742533,0.0001044388,0.0001658615,0.0001553548],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004363292,0.0004434371,0.886767,0.0001708163,0.00006643864,0.000001572875,0.00066232,0.00007218466,0.1078055,0.00007759091,0.0002698207,0.003227022],"study_design_scores_gemma":[0.002244928,0.001119046,0.4221008,0.002180825,0.0002130675,0.000002641179,0.0003749733,0.002662608,0.5648026,0.004128934,0.00004412825,0.0001254284],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987985,0.0001693774,0.00001591894,0.0004002971,0.0001441612,0.0001663096,0.000001122873,0.000004544592,0.0002997848],"genre_scores_gemma":[0.9927176,0.0002933924,0.006675239,0.0001380684,0.0001210603,0.000005385028,0.000003384841,0.000009837122,0.00003601669],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4646662,"threshold_uncertainty_score":0.376108,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08489625709867195,"score_gpt":0.3146943365462345,"score_spread":0.2297980794475626,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}