{"id":"W1976269797","doi":"10.1007/s00280-013-2372-x","title":"Phase 1b study of safety, tolerability and efficacy of R1507, a monoclonal antibody to IGF-1R in combination with multiple standard oncology regimens in patients with advanced solid malignancies","year":2014,"lang":"en","type":"article","venue":"Cancer Chemotherapy and Pharmacology","topic":"Growth Hormone and Insulin-like Growth Factors","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":false,"ca_institutions":"Georgetown Hospital","funders":"","keywords":"Tolerability; Monoclonal antibody; Medicine; Oncology; Internal medicine; Solid tumor; Pharmacology; Antibody; Immunology; Adverse effect; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002405506,0.0001830209,0.000743364,0.0001789943,0.00003184815,0.000002401329,0.00005720265,0.00008265494,0.00002704864],"category_scores_gemma":[0.00002416515,0.000141887,0.00001797603,0.0002752394,0.0001774562,0.00007699971,0.0000232833,0.0001684178,8.585221e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001260961,"about_ca_system_score_gemma":0.0001351793,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001454131,"about_ca_topic_score_gemma":0.0001969864,"domain_scores_codex":[0.9987168,0.0001254369,0.0004360873,0.0003357059,0.0001594199,0.000226538],"domain_scores_gemma":[0.9992017,0.0001802363,0.0001965191,0.0001228154,0.0001913786,0.0001073868],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0587697,0.008926642,0.8478065,0.0001385649,0.0001220372,0.000004795993,0.006228094,0.00007722606,0.05252402,0.000006532235,0.00002578343,0.0253701],"study_design_scores_gemma":[0.1490506,0.03522347,0.7703984,0.00009370548,0.00006863675,0.000001571441,0.000341052,0.0001688558,0.04403068,0.0000102859,0.0004677236,0.0001450122],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975668,0.0001440062,0.00008867508,0.0004243016,0.0000615281,0.001640803,0.0000286211,0.000009411917,0.00003583819],"genre_scores_gemma":[0.9989902,0.0002035568,0.0002286894,0.0004507598,0.0000181532,0.00006864696,0.00001687053,0.00001765929,0.000005491245],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09028093,"threshold_uncertainty_score":0.5785986,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01144108127884734,"score_gpt":0.3394824451145487,"score_spread":0.3280413638357013,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}