{"id":"W1976280255","doi":"10.1021/cs401065n","title":"Deracemization of 2-Methyl-1,2,3,4-Tetrahydroquinoline Using Mutant Cyclohexylamine Oxidase Obtained by Iterative Saturation Mutagenesis","year":2014,"lang":"en","type":"article","venue":"ACS Catalysis","topic":"Enzyme Catalysis and Immobilization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; National Research Council Canada; Centre in Green Chemistry and Catalysis","funders":"","keywords":"Saturated mutagenesis; Chemistry; Flavin group; Cyclohexylamine; Enantiomeric excess; Mutagenesis; Stereoselectivity; Substrate (aquarium); Kinetic resolution; Biocatalysis; Amine gas treating; Stereochemistry; Mutant; Combinatorial chemistry; Catalysis; Organic chemistry; Biochemistry; Enantioselective synthesis; Reaction mechanism; Biology; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002023392,0.0004422957,0.0002671365,0.0001375992,0.00008880773,0.000228859,0.0003458454,0.0002578134,0.0005139467],"category_scores_gemma":[0.0002185744,0.0001482495,0.0003178904,0.0001922051,0.0001806269,0.00011781,0.0002564662,0.0004026433,0.0002979803],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003422558,"about_ca_system_score_gemma":0.0003154757,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001945843,"about_ca_topic_score_gemma":0.002397642,"domain_scores_codex":[0.9998134,0.00003018966,0.00002194824,0.00004129543,0.00005115871,0.00004209939],"domain_scores_gemma":[0.9998568,0.0000302596,0.00004074788,0.0000239945,0.00003000308,0.00001808183],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000316217,0.00001295505,0.00008320126,0.00001377679,0.000004380576,0.00005602252,0.00001487645,0.000104652,0.9989811,0.00004592944,0.00001073312,0.0006406634],"study_design_scores_gemma":[0.000005980075,0.00006506014,0.0004198702,0.000002140337,0.000006675807,0.00008992584,0.00001451316,0.0007267906,0.9978179,0.00001284838,0.0008342873,0.00000402776],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9865269,0.0003002089,0.01157653,0.00005152397,0.0000242395,0.00007303859,0.0002531097,0.000100631,0.001093868],"genre_scores_gemma":[0.9892648,0.0003363533,0.007982561,0.00002855877,0.000003359625,0.00003885416,0.0005293595,0.00007772414,0.001738411],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001945843,"threshold_uncertainty_score":0.003869057,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00642414280092787,"score_gpt":0.238398678939893,"score_spread":0.2319745361389652,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}