{"id":"W1976292163","doi":"10.1073/pnas.1111966108","title":"Signal transducer and activator of transcription-6 (STAT6) inhibition suppresses renal cyst growth in polycystic kidney disease","year":2011,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Genetic and Kidney Cyst Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"National Institute of Diabetes and Digestive and Kidney Diseases","keywords":"STAT6; Polycystic kidney disease; Paracrine signalling; STAT protein; Cancer research; Cyst; Biology; Kidney; Signal transduction; Endocrinology; Internal medicine; Receptor; Cell biology; Medicine; Interleukin 4; Cytokine; Immunology; Pathology; STAT3","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001425457,0.0002177397,0.000267209,0.0002030394,0.0001066171,0.0002323233,0.0001441011,0.0002253117,0.001046357],"category_scores_gemma":[0.000103512,0.0000724116,0.0002066838,0.0001162922,0.0002185252,0.0001321705,0.0001172303,0.000662477,0.0002689037],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001686687,"about_ca_system_score_gemma":0.0002053698,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002611891,"about_ca_topic_score_gemma":0.0008465032,"domain_scores_codex":[0.9999133,0.00001767593,0.00001161618,0.000008911254,0.00002894287,0.0000195353],"domain_scores_gemma":[0.99994,0.000008707481,0.00001217079,0.000005090482,0.000007263573,0.00002672717],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009820889,0.0001998215,0.0006213674,0.0001035237,0.00001728752,0.00008578369,0.00001588142,0.0002108725,0.9887317,0.0002762519,0.0003656547,0.008389835],"study_design_scores_gemma":[0.0003157054,0.002164074,0.00892909,0.00001737682,0.00005430983,0.0008113218,0.00004939857,0.002535913,0.9757842,0.0001871661,0.009142921,0.000008509945],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988517,0.005107454,0.002529012,0.0004050166,0.0001605375,0.00003284209,0.0005028262,0.0002163054,0.002529125],"genre_scores_gemma":[0.9927891,0.002133637,0.001812381,0.0001317313,0.00002381314,0.00002516777,0.0005742178,0.0000158196,0.002494158],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001046357,"threshold_uncertainty_score":0.003500402,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02372522723248681,"score_gpt":0.2519020034107539,"score_spread":0.2281767761782671,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}