{"id":"W1976292163","doi":"10.1073/pnas.1111966108","title":"Signal transducer and activator of transcription-6 (STAT6) inhibition suppresses renal cyst growth in polycystic kidney disease","year":2011,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Genetic and Kidney Cyst Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"National Institute of Diabetes and Digestive and Kidney Diseases","keywords":"STAT6; Polycystic kidney disease; Paracrine signalling; STAT protein; Cancer research; Cyst; Biology; Kidney; Signal transduction; Endocrinology; Internal medicine; Receptor; Cell biology; Medicine; Interleukin 4; Cytokine; Immunology; Pathology; STAT3","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000240977,0.00008091882,0.0001002274,0.00008860591,0.00004999828,0.00000558799,0.0001963385,0.00005705915,0.00001949031],"category_scores_gemma":[0.0002311545,0.00005962721,0.0000562229,0.0001988138,0.0006318447,0.00002922673,0.00003238933,0.00004948063,8.886177e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000466741,"about_ca_system_score_gemma":0.00009001031,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001200293,"about_ca_topic_score_gemma":8.101951e-8,"domain_scores_codex":[0.9990985,0.000008880884,0.0002297781,0.0001978805,0.0003613571,0.0001036067],"domain_scores_gemma":[0.9996096,0.00001212048,0.0001503779,0.000007141633,0.0001265368,0.00009423655],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002393975,0.00009403476,0.007351615,0.000131773,0.00001083953,1.498296e-8,0.0001502534,0.000004003889,0.990778,0.0009749363,0.0002336302,0.00003149017],"study_design_scores_gemma":[0.0002936107,0.00007849522,0.1349608,0.00009758424,0.00001997409,0.000002612162,0.00009053266,0.00003618032,0.8557907,0.008542372,0.00002513937,0.00006205808],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983988,0.0002372527,0.000008630798,0.000486061,0.0000078677,0.0001250999,0.000151308,0.000001896768,0.000583073],"genre_scores_gemma":[0.9994081,0.00006872911,0.0003243873,0.0001338245,0.00002943153,0.00000977947,0.000001854799,0.000003595815,0.00002030104],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1349873,"threshold_uncertainty_score":0.2431527,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02372522723248681,"score_gpt":0.2519020034107539,"score_spread":0.2281767761782671,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}