{"id":"W1976336745","doi":"10.1016/j.ijrobp.2013.01.011","title":"Detection and Repair of Ionizing Radiation-Induced DNA Double Strand Breaks: New Developments in Nonhomologous End Joining","year":2013,"lang":"en","type":"review","venue":"International Journal of Radiation Oncology*Biology*Physics","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":158,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"National Cancer Institute; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Non-homologous end joining; DNA repair; Genome instability; DNA damage; Replication protein A; Homology directed repair; DNA repair protein XRCC4; DNA; Ionizing radiation; Homologous recombination; Cell biology; DNA replication; Biology; Genetics; DNA mismatch repair; Gene; DNA-binding protein; Irradiation; Physics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00078365,0.0003986994,0.001124119,0.0003720857,0.00005772646,0.00003520125,0.0004668551,0.0008576965,0.00001902575],"category_scores_gemma":[0.0002603426,0.0003785546,0.0004056317,0.0002012868,0.00008955813,0.00005629533,0.0001511157,0.0005271961,0.000007964988],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004581985,"about_ca_system_score_gemma":0.001502611,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006646445,"about_ca_topic_score_gemma":0.00003216067,"domain_scores_codex":[0.9971155,0.0003548042,0.001537226,0.0004543077,0.0002555832,0.0002825818],"domain_scores_gemma":[0.9965757,0.0001752255,0.002477941,0.0002137993,0.0004140733,0.0001433154],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001148771,0.0001284804,0.00129425,0.0001714724,0.000842644,0.00001471475,0.0001398078,0.00003731392,0.01370981,0.0003504859,0.00009445786,0.9831017],"study_design_scores_gemma":[0.01454609,0.003581886,0.002120694,0.002811787,0.0009907248,0.001681889,0.0001542412,0.0003342008,0.05640116,0.00283405,0.9129678,0.001575463],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.1643671,0.8226376,0.005838399,0.00009699419,0.00507994,0.00133954,0.00007712681,0.00005320649,0.0005100243],"genre_scores_gemma":[0.1306749,0.8620337,0.004752978,0.0001024605,0.001937392,0.00004598735,0.0002860607,0.00008218811,0.00008441031],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9815262,"threshold_uncertainty_score":0.9998667,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03371701605452813,"score_gpt":0.3316248202775484,"score_spread":0.2979078042230202,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}