{"id":"W1976368672","doi":"10.1021/jm301511h","title":"Discovery of Agonists of Cannabinoid Receptor 1 with Restricted Central Nervous System Penetration Aimed for Treatment of Gastroesophageal Reflux Disease","year":2012,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"AstraZeneca (Canada)","funders":"","keywords":"Cannabinoid receptor; Chemistry; Pharmacology; Cannabinoid; Cannabinoid Receptor Agonists; GERD; Receptor; Central nervous system; Agonist; Reflux; Internal medicine; Disease; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001555189,0.0003989177,0.0005957122,0.0005330904,0.0001895229,0.000336947,0.0003190788,0.0002803625,0.001839166],"category_scores_gemma":[0.0001670056,0.0002116249,0.0003450734,0.0002878272,0.0001643951,0.0002341885,0.0002482564,0.0005974809,0.0004140974],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002697316,"about_ca_system_score_gemma":0.0002965101,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006633435,"about_ca_topic_score_gemma":0.002743967,"domain_scores_codex":[0.9999254,0.00001352907,0.000004858348,0.00001274608,0.00001812661,0.00002533483],"domain_scores_gemma":[0.9999621,0.000007299656,0.000008852308,0.000003117991,0.000007926023,0.00001081651],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004094447,0.0003123938,0.0002400044,0.0002782548,0.00003384407,0.0003690449,0.00006965995,0.0005352597,0.9638439,0.0005975334,0.0003262206,0.03298442],"study_design_scores_gemma":[0.0009303096,0.01088957,0.006755977,0.0001938437,0.0003384275,0.002708335,0.0001244878,0.002847177,0.9436907,0.0005164716,0.03094447,0.00006018505],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9545982,0.02661371,0.006520512,0.0005821445,0.00009635725,0.0004219273,0.0006400457,0.0001719073,0.01035517],"genre_scores_gemma":[0.9719473,0.01815293,0.00554604,0.0003131505,0.00004093664,0.000100777,0.000511758,0.00002294658,0.003364261],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001839166,"threshold_uncertainty_score":0.00615263,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01385280618013444,"score_gpt":0.2799728264476766,"score_spread":0.2661200202675421,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}