{"id":"W1976407358","doi":"10.1016/j.cell.2004.11.050","title":"Mammalian Staufen1 Recruits Upf1 to Specific mRNA 3′UTRs so as to Elicit mRNA Decay","year":2005,"lang":"en","type":"article","venue":"Cell","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":501,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"","keywords":"Nonsense-mediated decay; Biology; Messenger RNA; Untranslated region; P-bodies; RNA-binding protein; RNA splicing; Cell biology; Translation (biology); Exon; RNA; Three prime untranslated region; Precursor mRNA; Molecular biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006239309,0.0005813922,0.0004885512,0.0004215002,0.0006800334,0.0008043607,0.0003118951,0.0006556567,0.002291046],"category_scores_gemma":[0.0006301983,0.000374965,0.0007451966,0.0002546842,0.0004801656,0.0005204538,0.0006891986,0.00124712,0.001237475],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009882225,"about_ca_system_score_gemma":0.0003448819,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005562906,"about_ca_topic_score_gemma":0.001556516,"domain_scores_codex":[0.9996402,0.00005023209,0.00002619012,0.0001028437,0.0000873467,0.00009311452],"domain_scores_gemma":[0.9995468,0.0001534089,0.00007106582,0.00006999354,0.00006147771,0.00009723556],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001172561,0.00001871969,0.0002302431,0.00003673575,0.0000051667,0.00005864118,0.00002775757,0.0000990849,0.9969002,0.0004064926,0.0001372712,0.001962534],"study_design_scores_gemma":[0.000007754447,0.0000458303,0.00119674,0.000003360967,0.000004407858,0.0001180495,0.00002182742,0.0007270579,0.9952519,0.0001060865,0.002512551,0.000004573414],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.960999,0.004698091,0.02738016,0.0006883486,0.0002773501,0.0001020337,0.0007464137,0.0005682367,0.004540491],"genre_scores_gemma":[0.9792047,0.000918761,0.01126896,0.0003010036,0.00004868517,0.00006067617,0.00173919,0.0001604388,0.006297428],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002291046,"threshold_uncertainty_score":0.007664323,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01886084715709707,"score_gpt":0.2837719879397497,"score_spread":0.2649111407826527,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}