{"id":"W1976407358","doi":"10.1016/j.cell.2004.11.050","title":"Mammalian Staufen1 Recruits Upf1 to Specific mRNA 3′UTRs so as to Elicit mRNA Decay","year":2005,"lang":"en","type":"article","venue":"Cell","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":501,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"","keywords":"Nonsense-mediated decay; Biology; Messenger RNA; Untranslated region; P-bodies; RNA-binding protein; RNA splicing; Cell biology; Translation (biology); Exon; RNA; Three prime untranslated region; Precursor mRNA; Molecular biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002302379,0.0001933436,0.000158597,0.00009522241,0.0001296163,0.00009779525,0.0004108952,0.0001322555,0.0003323667],"category_scores_gemma":[0.00004015833,0.0001888306,0.00009421293,0.0001811388,0.00003289059,0.000005048209,0.0002077276,0.0001377095,0.002315051],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000503926,"about_ca_system_score_gemma":0.00009878252,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000770202,"about_ca_topic_score_gemma":0.0002251823,"domain_scores_codex":[0.9983441,0.00004676074,0.0002210709,0.0005101649,0.0002488996,0.0006289514],"domain_scores_gemma":[0.9987073,0.00001161611,0.00003572393,0.000569412,0.00009771057,0.0005782337],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001074543,0.00005072443,0.000127351,0.000009508426,0.000009545207,0.00001540851,0.0001134098,0.0001509491,0.9298568,0.00002637686,0.0531521,0.01638036],"study_design_scores_gemma":[0.0001967621,0.0002266477,0.0001914284,0.00000763175,0.000001988152,0.000004436302,0.00006073653,0.000004758899,0.5218086,0.00000601847,0.4773508,0.0001401806],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9720642,0.000657714,0.0004936328,0.001492408,0.0001227815,0.0003792825,0.00001446094,0.00001922989,0.02475632],"genre_scores_gemma":[0.9123933,0.0002904372,0.002735711,0.002023211,0.0008676695,0.00003760482,0.00004449536,0.00004792099,0.08155964],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4241987,"threshold_uncertainty_score":0.9984618,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01886084715709707,"score_gpt":0.2837719879397497,"score_spread":0.2649111407826527,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}