{"id":"W1976449858","doi":"10.1097/00007890-200007270-00017","title":"IMMUNOPHILINS MAY LIMIT CALCINEURIN INHIBITION BY CYCLOSPORINE AND TACROLIMUS AT HIGH DRUG CONCENTRATIONS1","year":2000,"lang":"en","type":"article","venue":"Transplantation","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":98,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Calcineurin; Phosphatase; Dephosphorylation; Potency; Pharmacology; Tacrolimus; Chemistry; IC50; In vivo; Biochemistry; In vitro; Biology; Transplantation; Enzyme; Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005673197,0.0001208267,0.0000789968,0.00001382402,0.0001000315,0.00001593261,0.00004439682,0.00007154749,0.0001830072],"category_scores_gemma":[0.000004115469,0.0001290521,0.00003162696,0.00004454923,0.00005910215,0.000007739273,0.000005792187,0.00004809723,0.00002418563],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001480512,"about_ca_system_score_gemma":0.00001778163,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005596734,"about_ca_topic_score_gemma":0.00003626668,"domain_scores_codex":[0.9992892,0.00004279485,0.0001700685,0.0002545458,0.00009932794,0.0001440962],"domain_scores_gemma":[0.9997198,0.00001197922,0.00003565927,0.0001390593,0.00002534265,0.00006815943],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005735058,0.00006671201,0.002571354,0.00004607518,0.00002075684,0.00001767087,0.0001835804,0.0002564984,0.9937352,0.00005508913,0.001040972,0.001432597],"study_design_scores_gemma":[0.001779643,0.00009685858,0.009461642,0.0000233525,0.00006011282,0.00004517961,0.00001049487,0.00003747431,0.9849358,0.00005865173,0.003302988,0.0001877834],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979957,0.0006106267,0.000159811,0.000243282,0.00005725579,0.0001761878,0.0003841336,0.00002744527,0.0003455652],"genre_scores_gemma":[0.9930167,0.001762699,0.00009043096,0.0002297736,0.0000923912,0.00002320896,0.003712542,0.00001731817,0.001054909],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00879937,"threshold_uncertainty_score":0.5262592,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003621413177148838,"score_gpt":0.2078297440577574,"score_spread":0.2042083308806086,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}