{"id":"W1976449858","doi":"10.1097/00007890-200007270-00017","title":"IMMUNOPHILINS MAY LIMIT CALCINEURIN INHIBITION BY CYCLOSPORINE AND TACROLIMUS AT HIGH DRUG CONCENTRATIONS1","year":2000,"lang":"en","type":"article","venue":"Transplantation","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":98,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Calcineurin; Phosphatase; Dephosphorylation; Potency; Pharmacology; Tacrolimus; Chemistry; IC50; In vivo; Biochemistry; In vitro; Biology; Transplantation; Enzyme; Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002175343,0.0002597455,0.0002440605,0.0001754047,0.000159815,0.0004520406,0.0001711794,0.000336493,0.001227654],"category_scores_gemma":[0.0003704542,0.0001018459,0.0002133283,0.0001083712,0.0002245388,0.0001966025,0.0001574733,0.0003666077,0.0002864065],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002581112,"about_ca_system_score_gemma":0.000207119,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003658777,"about_ca_topic_score_gemma":0.0007235114,"domain_scores_codex":[0.9998108,0.00004007384,0.00001928155,0.00002554059,0.00005651457,0.0000478165],"domain_scores_gemma":[0.9997813,0.00007318728,0.00006259269,0.00001429423,0.00003148898,0.00003719546],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001119511,0.00002155896,0.0006883713,0.00005855652,0.000009199079,0.00004338912,0.000007835799,0.00009168743,0.9948954,0.0001137349,0.00005561495,0.003902572],"study_design_scores_gemma":[0.00001300978,0.0005559078,0.01608263,0.000009457415,0.00005132029,0.0005152064,0.00001569487,0.001251703,0.978336,0.00007082612,0.003093742,0.000004445361],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9820616,0.009120849,0.004287208,0.0001466998,0.0000419981,0.00003877353,0.0001377953,0.0000955151,0.004069528],"genre_scores_gemma":[0.9962936,0.001195028,0.001507063,0.00005576848,0.00003241201,0.00001653714,0.00009914189,0.000008911467,0.0007914278],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001227654,"threshold_uncertainty_score":0.004106879,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003621413177148838,"score_gpt":0.2078297440577574,"score_spread":0.2042083308806086,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}