{"id":"W1976475623","doi":"10.1093/nar/gks723","title":"DNA of a circular minichromosome linearized by restriction enzymes or other reagents is resistant to further cleavage: an influence of chromatin topology on the accessibility of DNA","year":2012,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"","keywords":"Minichromosome; Biology; Chromatin; DNA; Histone; Nucleosome; Cleavage (geology); Restriction enzyme; Molecular biology; Deoxyribonuclease I; Topoisomerase; DNA supercoil; Cell biology; DNA replication; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002377953,0.0002091093,0.0001865967,0.0001327531,0.0001018698,0.0003493864,0.0001875836,0.0003069499,0.001120651],"category_scores_gemma":[0.0004323484,0.0002441502,0.0001625557,0.00009015281,0.000289114,0.0002337647,0.0001498611,0.0003660179,0.0002873334],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001269483,"about_ca_system_score_gemma":0.00008600697,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002214373,"about_ca_topic_score_gemma":0.0003457811,"domain_scores_codex":[0.9998487,0.00002945209,0.000009530994,0.00004962219,0.00003863574,0.00002398115],"domain_scores_gemma":[0.99955,0.0001614127,0.0001326839,0.00004500583,0.00003681149,0.00007400475],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000189708,0.000002225863,0.00008433578,0.00000903747,0.000001589089,0.000009970212,0.000007879118,0.00001092038,0.9996459,0.00001512551,0.000002125765,0.0001918448],"study_design_scores_gemma":[0.000004209362,0.0001306778,0.004984468,0.000003616371,0.000008201459,0.0002369804,0.00001665537,0.0003156205,0.9937723,0.00002252664,0.0005015539,0.000003186926],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957235,0.0005859979,0.003118101,0.00003687583,0.000006271889,0.000009695424,0.00004558514,0.00002260231,0.0004513412],"genre_scores_gemma":[0.9969454,0.0002923826,0.001860188,0.00002412359,0.000004332701,0.00001045212,0.0001765335,0.0000180574,0.0006685114],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001120651,"threshold_uncertainty_score":0.003748953,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03772399354009254,"score_gpt":0.3443597657793864,"score_spread":0.3066357722392939,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}