{"id":"W1976481941","doi":"10.1016/j.vaccine.2008.08.045","title":"Intranasal and subcutaneous immunization under the effect of estradiol leads to better protection against genital HSV-2 challenge compared to progesterone","year":2008,"lang":"en","type":"article","venue":"Vaccine","topic":"Herpesvirus Infections and Treatments","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research; Health Canada; Ontario HIV Treatment Network; Canadian Foundation for AIDS Research; amfAR, The Foundation for AIDS Research","keywords":"Immunization; Nasal administration; Placebo; Immunology; Immune system; Hormone; Medicine; Intravaginal administration; Subcutaneous injection; Vagina; Vaccination; Viral shedding; Internal medicine; Antibody; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002020423,0.0003232725,0.0005935426,0.0002459415,0.0001383535,0.0003953303,0.0002228993,0.0003902177,0.003237802],"category_scores_gemma":[0.000387432,0.0001618963,0.000303591,0.0001562938,0.0003825445,0.0004161907,0.0001766889,0.001104446,0.0008072036],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001267084,"about_ca_system_score_gemma":0.000324451,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005616636,"about_ca_topic_score_gemma":0.000511597,"domain_scores_codex":[0.9997575,0.0000434012,0.00001562896,0.00005171657,0.00004041889,0.00009144223],"domain_scores_gemma":[0.9997885,0.00005599977,0.00004082311,0.00004358568,0.00001815565,0.00005292929],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006855166,0.0009718006,0.0009444872,0.0001386002,0.00002740764,0.00009225026,0.00008093248,0.00009032364,0.9783787,0.0001408564,0.0002438913,0.01203558],"study_design_scores_gemma":[0.000653666,0.0223203,0.01748003,0.00004209157,0.0001630109,0.0007086275,0.0002518786,0.0004533957,0.9531294,0.000236041,0.004540701,0.00002084383],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965976,0.00136831,0.0004742278,0.0001347414,0.0001340728,0.00001975308,0.0001355782,0.00003571389,0.001100044],"genre_scores_gemma":[0.9946313,0.001002303,0.0005244265,0.00006946678,0.00004914895,0.00002336287,0.0003322784,0.00001858874,0.003349064],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003237802,"threshold_uncertainty_score":0.01083159,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01775361668670693,"score_gpt":0.2541346352756731,"score_spread":0.2363810185889662,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}