{"id":"W1976497124","doi":"10.1371/journal.ppat.1003420","title":"Glycan Masking of Plasmodium vivax Duffy Binding Protein for Probing Protein Binding Function and Vaccine Development","year":2013,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Research Council Canada","keywords":"Glycan; Biology; Epitope; Immunogenicity; Glycoprotein; Immunogen; Glycosylation; Plasmodium vivax; Binding site; Virology; Antibody; Computational biology; Monoclonal antibody; Biochemistry; Genetics; Immunology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002204063,0.0002066861,0.0002918796,0.0002275846,0.0003446644,0.00002841846,0.0001001817,0.0001522802,0.0002101892],"category_scores_gemma":[0.00009327852,0.0001712721,0.00005440072,0.0001347252,0.00004410434,0.0001246068,0.00009624003,0.0001593835,0.0002984702],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000097504,"about_ca_system_score_gemma":0.0001034738,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002381646,"about_ca_topic_score_gemma":0.00001539263,"domain_scores_codex":[0.9986163,0.00008441263,0.0003423816,0.0003577124,0.00006771584,0.0005314982],"domain_scores_gemma":[0.9994485,0.00006505577,0.000154586,0.0001649624,0.0001128065,0.00005413452],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001834868,0.0001962984,0.003256072,0.0002173247,0.0003085311,0.000002807435,0.0003929571,7.12118e-7,0.9889213,0.0001439562,0.00005552547,0.006321073],"study_design_scores_gemma":[0.002265875,0.0005997285,0.002692011,0.0003054536,0.00004823479,0.00001004371,0.000326122,0.00001831825,0.9921314,0.00008179988,0.001313814,0.0002072311],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952968,0.0001819813,0.0006285401,0.0001313351,0.0000606169,0.003420648,0.0000860818,0.00005913143,0.0001349064],"genre_scores_gemma":[0.9921947,0.000004354114,0.003254667,0.000004973093,0.00001927179,0.001999161,0.000253589,0.00002970314,0.002239592],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006113841,"threshold_uncertainty_score":0.6984272,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02181897673911013,"score_gpt":0.2264232297941495,"score_spread":0.2046042530550394,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}