{"id":"W1976551786","doi":"10.1074/jbc.m202898200","title":"The N-terminal Coiled Coil Domain of the Cytohesin/ARNO Family of Guanine Nucleotide Exchange Factors Interacts with the Scaffolding Protein CASP","year":2002,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"","keywords":"Guanine nucleotide exchange factor; Coiled coil; Cell biology; Pleckstrin homology domain; Scaffold protein; ADP ribosylation factor; Biology; CASP; Chemistry; Molecular biology; GTPase; Protein structure; Golgi apparatus; Signal transduction; Biochemistry; Endoplasmic reticulum","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006777419,0.0002387501,0.0001535576,0.0001637805,0.0001877376,0.0001664993,0.00009771149,0.0001799872,0.00101125],"category_scores_gemma":[0.000110694,0.00007457393,0.0002204552,0.0001187129,0.000156383,0.0001549094,0.0002086414,0.0002419748,0.0004460404],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002974308,"about_ca_system_score_gemma":0.0001224918,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003917134,"about_ca_topic_score_gemma":0.0008187129,"domain_scores_codex":[0.9999408,0.000009739516,0.000002503364,0.00001500241,0.00001726501,0.00001471195],"domain_scores_gemma":[0.9999117,0.00002237153,0.00002247917,0.00000729512,0.000009289553,0.00002684806],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006982318,0.00001135636,0.001260877,0.00001856302,0.000004317976,0.0002052309,0.0000108199,0.00007509359,0.9971853,0.00006819201,0.0000469504,0.001043509],"study_design_scores_gemma":[0.00002015018,0.000103372,0.05778026,0.00000749798,0.00001465221,0.001428139,0.00007292178,0.002850234,0.9324429,0.0001572872,0.005114066,0.000008552671],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967783,0.0005241095,0.001464524,0.00006780531,0.000008970309,0.000006523917,0.0001185421,0.00002957298,0.00100173],"genre_scores_gemma":[0.9958255,0.0002712205,0.001848407,0.00006454769,0.000007980354,0.000007734588,0.0005702677,0.000007749177,0.001396594],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00101125,"threshold_uncertainty_score":0.003382981,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01776480027945568,"score_gpt":0.2096106533313913,"score_spread":0.1918458530519357,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}