{"id":"W1976602152","doi":"10.1523/jneurosci.5416-06.2007","title":"“Breakthrough” Dopamine Supersensitivity during Ongoing Antipsychotic Treatment Leads to Treatment Failure over Time","year":2007,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Neurotransmitter Receptor Influence on Behavior","field":"Neuroscience","cited_by":262,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University; University of Toronto; Centre for Addiction and Mental Health","funders":"Canadian Institutes of Health Research; Stanley Medical Research Institute","keywords":"Antipsychotic; Neurochemical; Dopamine; Dopamine receptor D2; Haloperidol; Dopaminergic; Pharmacology; Medicine; Olanzapine; Typical antipsychotic; Tardive dyskinesia; Psychology; Dopamine receptor; Neuroscience; Internal medicine; Atypical antipsychotic; Schizophrenia (object-oriented programming); Psychiatry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006352663,0.0003210525,0.0006801977,0.0002213128,0.0001965571,0.0003322889,0.0002302811,0.0003973513,0.001088582],"category_scores_gemma":[0.001014861,0.0001454377,0.0004273556,0.0001822939,0.0002462169,0.000278136,0.0002805788,0.0006658527,0.0003068685],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004756008,"about_ca_system_score_gemma":0.0002906288,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007889851,"about_ca_topic_score_gemma":0.001373549,"domain_scores_codex":[0.9996079,0.00007345355,0.00004252962,0.00005937114,0.0001435984,0.00007321883],"domain_scores_gemma":[0.9991736,0.0001563903,0.0004012803,0.00007187873,0.00006668967,0.0001301458],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.005249233,0.0008201379,0.1352122,0.0004376677,0.0006173133,0.003663241,0.0006497588,0.0008810621,0.7356337,0.0006344888,0.0007996326,0.1154017],"study_design_scores_gemma":[0.00013671,0.01310109,0.870996,0.00008762697,0.0004175482,0.009888665,0.0003648046,0.002419331,0.09658462,0.0005660215,0.005388768,0.00004873075],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976332,0.0009775052,0.0005132337,0.00007805028,0.000007407146,0.0000168133,0.0000618648,0.00003003478,0.0006817617],"genre_scores_gemma":[0.9988396,0.0003846066,0.0002139697,0.00008532126,0.000009633941,0.00001328428,0.0001289642,0.000009063569,0.0003156398],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001088582,"threshold_uncertainty_score":0.003641665,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03512993965430115,"score_gpt":0.3113403863247839,"score_spread":0.2762104466704827,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}