{"id":"W1976605228","doi":"10.1158/0008-5472.can-04-4575","title":"A Hypoxia-Driven Vascular Endothelial Growth Factor/Flt1 Autocrine Loop Interacts with Hypoxia-Inducible Factor-1α through Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase 1/2 Pathway in Neuroblastoma","year":2005,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":127,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"Hospital for Sick Children","keywords":"Autocrine signalling; Vascular endothelial growth factor; Angiogenesis; MAPK/ERK pathway; Cancer research; Signal transduction; Paracrine signalling; Biology; Vascular endothelial growth factor A; Kinase; Cell biology; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001171643,0.00023277,0.0002288106,0.0001000327,0.0001574513,0.000189232,0.0001544483,0.0001335963,0.0005795225],"category_scores_gemma":[0.00007351614,0.0001492688,0.0002170375,0.00007574706,0.0001367112,0.0001560041,0.0001238916,0.0003093592,0.0001921293],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004438116,"about_ca_system_score_gemma":0.0002513693,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002823829,"about_ca_topic_score_gemma":0.004124253,"domain_scores_codex":[0.9999369,0.000007899456,0.000007449471,0.00001430281,0.00001935933,0.00001417055],"domain_scores_gemma":[0.9999659,0.000004726602,0.000007720238,0.000005612865,0.000004764772,0.00001127562],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006435077,0.000008306181,0.0001289962,0.00002113274,0.000002024339,0.00005874591,0.00001392403,0.00003062426,0.9992914,0.00004811366,0.00001793213,0.0003144234],"study_design_scores_gemma":[0.00002563566,0.0001889503,0.009798293,0.000006686027,0.00001948566,0.0006777561,0.00003756375,0.001220834,0.9848978,0.00004851052,0.003073844,0.000004697473],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994562,0.00228943,0.001717177,0.00005195532,0.00002029954,0.00002200401,0.0003548769,0.00004224953,0.0009401185],"genre_scores_gemma":[0.9927295,0.001475845,0.001548095,0.00002708117,0.000007860076,0.00005287058,0.000892537,0.00000982444,0.003256439],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002823829,"threshold_uncertainty_score":0.005614758,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03493867526904716,"score_gpt":0.3024512578544751,"score_spread":0.2675125825854279,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}