{"id":"W1976608900","doi":"10.4161/cc.27396","title":"Rapamycin induces pluripotent genes associated with avoidance of replicative senescence","year":2013,"lang":"en","type":"article","venue":"Cell Cycle","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Russian Academy of Sciences; Saint Petersburg State University; University of Toronto","keywords":"Biology; Telomere; Cell biology; Telomerase; Senescence; Embryonic stem cell; Induced pluripotent stem cell; Cell cycle; mTORC1; Homeobox protein NANOG; Cell cycle checkpoint; Gene; Molecular biology; Genetics; PI3K/AKT/mTOR pathway; Signal transduction","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001193934,0.0003776971,0.0002413922,0.0003138725,0.0001060298,0.0001874282,0.0001424867,0.0001934281,0.001325308],"category_scores_gemma":[0.0001023035,0.0001337198,0.0002449864,0.0001568549,0.000190071,0.0001159401,0.0001733288,0.0003841739,0.0003418243],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001745611,"about_ca_system_score_gemma":0.0001790339,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002238317,"about_ca_topic_score_gemma":0.0005348223,"domain_scores_codex":[0.999884,0.00002492245,0.00001822599,0.00002136523,0.00002563001,0.00002583965],"domain_scores_gemma":[0.9998587,0.00002913403,0.00005056682,0.00001899505,0.00001255228,0.0000300593],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009602628,0.00002018886,0.0001447071,0.00004507121,0.000004357619,0.00005747509,0.00001336242,0.00003687551,0.9981224,0.000100938,0.0000397304,0.001318825],"study_design_scores_gemma":[0.00001382232,0.0005783559,0.003561539,0.000006195061,0.00001931988,0.0002838433,0.00001116588,0.0002554008,0.9922276,0.00003194839,0.003007057,0.000003762084],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903929,0.003132688,0.002545838,0.00008795388,0.000045001,0.00007769583,0.0007604921,0.0002853249,0.002672032],"genre_scores_gemma":[0.9911547,0.001678895,0.003015393,0.00006828854,0.00001973464,0.00008813274,0.001203497,0.00003954726,0.002731801],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001325308,"threshold_uncertainty_score":0.004433572,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01083732877310015,"score_gpt":0.2174575153980636,"score_spread":0.2066201866249635,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}