{"id":"W1976608900","doi":"10.4161/cc.27396","title":"Rapamycin induces pluripotent genes associated with avoidance of replicative senescence","year":2013,"lang":"en","type":"article","venue":"Cell Cycle","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Russian Academy of Sciences; Saint Petersburg State University; University of Toronto","keywords":"Biology; Telomere; Cell biology; Telomerase; Senescence; Embryonic stem cell; Induced pluripotent stem cell; Cell cycle; mTORC1; Homeobox protein NANOG; Cell cycle checkpoint; Gene; Molecular biology; Genetics; PI3K/AKT/mTOR pathway; Signal transduction","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000148307,0.0002007229,0.0004000238,0.000083787,0.00008120503,0.00001544278,0.0001693314,0.0001030885,0.0001727547],"category_scores_gemma":[0.0001082752,0.0001527022,0.00007064867,0.0003838421,0.0002203889,0.0001351534,0.00004132169,0.0001917977,0.00009586736],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005939625,"about_ca_system_score_gemma":0.0001147134,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003587807,"about_ca_topic_score_gemma":0.00002280024,"domain_scores_codex":[0.9985386,0.00006314323,0.000321671,0.00040616,0.000339499,0.0003308922],"domain_scores_gemma":[0.9985913,0.0001115577,0.0002611151,0.0005328889,0.0003252639,0.0001778695],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000103446,0.0005586743,0.05211869,0.0001523836,0.00007968998,0.00002919504,0.001254853,0.00002625238,0.93152,0.00003235279,0.0009306014,0.01319389],"study_design_scores_gemma":[0.001079962,0.0003925973,0.3064672,0.0002629223,0.0000567651,0.0000144535,0.0006695544,0.0002492472,0.6901553,0.00006931974,0.0003575139,0.0002252015],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946133,0.001039711,0.0001227039,0.0004530546,0.00006118124,0.000528634,0.000008010858,0.00008883219,0.003084546],"genre_scores_gemma":[0.996662,0.0002091208,0.0008231901,0.0002411627,0.00005485489,0.00004944208,0.00001762614,0.00002930595,0.00191334],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2543485,"threshold_uncertainty_score":0.6227015,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01083732877310015,"score_gpt":0.2174575153980636,"score_spread":0.2066201866249635,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}