{"id":"W1976622827","doi":"10.1016/j.bbagen.2015.01.003","title":"HIV-1 Nef: a master manipulator of the membrane trafficking machinery mediating immune evasion","year":2015,"lang":"en","type":"review","venue":"Biochimica et Biophysica Acta (BBA) - General Subjects","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":73,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research","keywords":"Biology; Immune system; Major histocompatibility complex; Viral pathogenesis; MHC class I; Evasion (ethics); Cell biology; Computational biology; Virology; Genetics; Virus; Viral replication","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005947806,0.001008147,0.002385107,0.000299256,0.0003045491,0.00006379284,0.001251848,0.0008097615,0.0001233045],"category_scores_gemma":[0.0001273995,0.0006125986,0.001351513,0.0006485705,0.0003737172,0.0001249087,0.0007669018,0.00117562,0.0007090306],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002443861,"about_ca_system_score_gemma":0.0008459404,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001400006,"about_ca_topic_score_gemma":0.00001576929,"domain_scores_codex":[0.995029,0.001513893,0.001172904,0.0009450664,0.0003311917,0.001007884],"domain_scores_gemma":[0.9971173,0.0002884133,0.001024654,0.001290946,0.0001424166,0.0001362968],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002693727,0.001002518,0.000006360325,0.005793763,0.003196238,0.00003761403,0.0008545935,0.000004560025,0.8368959,0.0001465296,0.003709962,0.1480826],"study_design_scores_gemma":[0.005640054,0.00109975,0.000518491,0.01087366,0.004258266,0.000402005,0.0001203273,0.00002851203,0.5637264,0.00005373372,0.4105743,0.002704516],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.2204722,0.7750996,0.000001291478,0.000225962,0.001024739,0.001591462,0.0009550194,0.00009953344,0.0005301392],"genre_scores_gemma":[0.1592531,0.8324263,0.0001680462,0.0000827782,0.000492955,0.000242242,0.004816064,0.0002152219,0.002303264],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.4068643,"threshold_uncertainty_score":0.9996325,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05562197927699326,"score_gpt":0.3052975642527293,"score_spread":0.2496755849757361,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}