{"id":"W1976650973","doi":"10.2478/s11658-010-0037-x","title":"Regulation of thrombospondin-1 expression through AU-rich elements in the 3′UTR of the mRNA","year":2010,"lang":"en","type":"article","venue":"Cellular & Molecular Biology Letters","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Institut National de la Santé et de la Recherche Médicale; Natural Sciences and Engineering Research Council of Canada; Ontario Ministry of Agriculture, Food and Rural Affairs","keywords":"Messenger RNA; Untranslated region; RNA-binding protein; Three prime untranslated region; Post-transcriptional regulation; AU-rich element; Gene expression; Molecular biology; Biology; RNA; Regulation of gene expression; Cell biology; Reporter gene; Chemistry; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001842044,0.0001943299,0.0002342173,0.0001766612,0.0002003015,0.0003276955,0.00012865,0.0001797868,0.0007390308],"category_scores_gemma":[0.0002684862,0.0001482241,0.0002964807,0.00009263174,0.000276951,0.0001377812,0.0001509715,0.000483672,0.0003602245],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004708192,"about_ca_system_score_gemma":0.0002211406,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006681551,"about_ca_topic_score_gemma":0.0009854556,"domain_scores_codex":[0.9998116,0.00003843322,0.00001367575,0.00006100439,0.00004160265,0.00003370117],"domain_scores_gemma":[0.9998109,0.00007096538,0.00004168626,0.00001566274,0.00003760907,0.00002319946],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003771578,0.000009051839,0.0001145192,0.00001653552,0.000001763333,0.00001769889,0.00001867805,0.0000461339,0.9990225,0.0001097775,0.00002735726,0.000578192],"study_design_scores_gemma":[0.00001033084,0.000108403,0.006322209,0.000008822462,0.00001091798,0.0001193839,0.00002997013,0.002519484,0.9886747,0.00008217423,0.00210661,0.000007002409],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886069,0.00174195,0.007505544,0.0001326599,0.00005888542,0.00002736803,0.0002880915,0.0001243273,0.001514253],"genre_scores_gemma":[0.988642,0.0005853318,0.007283753,0.000102673,0.00001427161,0.00004272073,0.0005603276,0.00003834779,0.002730494],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007390308,"threshold_uncertainty_score":0.003416061,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008400402322132398,"score_gpt":0.2710802571962581,"score_spread":0.2626798548741257,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}