{"id":"W1976650973","doi":"10.2478/s11658-010-0037-x","title":"Regulation of thrombospondin-1 expression through AU-rich elements in the 3′UTR of the mRNA","year":2010,"lang":"en","type":"article","venue":"Cellular & Molecular Biology Letters","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Institut National de la Santé et de la Recherche Médicale; Natural Sciences and Engineering Research Council of Canada; Ontario Ministry of Agriculture, Food and Rural Affairs","keywords":"Messenger RNA; Untranslated region; RNA-binding protein; Three prime untranslated region; Post-transcriptional regulation; AU-rich element; Gene expression; Molecular biology; Biology; RNA; Regulation of gene expression; Cell biology; Reporter gene; Chemistry; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005646458,0.0001514565,0.0001763726,0.00005159422,0.0000804888,0.000007740698,0.0006610539,0.0001945507,0.00001636331],"category_scores_gemma":[0.0001379683,0.00009441199,0.0001400356,0.0002018611,0.0003725236,0.000005773762,0.000192418,0.0002679125,0.000001821572],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000106459,"about_ca_system_score_gemma":0.00005723061,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008255668,"about_ca_topic_score_gemma":0.0000369635,"domain_scores_codex":[0.9984847,0.0003541582,0.0003412016,0.0003015157,0.0002001276,0.0003183524],"domain_scores_gemma":[0.998924,0.00002708779,0.0001989425,0.0007650891,0.00005724768,0.00002764061],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003420574,0.00005215585,0.02426018,0.00001528436,0.00002763953,0.000002634255,0.0001227193,0.00002507721,0.9745818,0.0005087943,0.0002289521,0.0001405034],"study_design_scores_gemma":[0.0004318106,0.00008997952,0.01274501,0.00001688396,0.00001194248,0.000004389629,0.00005811643,0.00002225957,0.9848914,0.0002927422,0.001338621,0.00009683177],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949734,0.0001670847,0.003133097,0.0008859649,0.0001721914,0.0004022011,0.000008005978,0.000002841279,0.0002551786],"genre_scores_gemma":[0.9981912,0.00001468665,0.0008800427,0.0006768805,0.00006682808,0.00002947097,0.00008030384,0.00001542685,0.0000451745],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01151517,"threshold_uncertainty_score":0.3850009,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008400402322132398,"score_gpt":0.2710802571962581,"score_spread":0.2626798548741257,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}