{"id":"W1976670151","doi":"10.1016/j.immuni.2009.11.013","title":"Dependence of T Cell Antigen Recognition on T Cell Receptor-Peptide MHC Confinement Time","year":2010,"lang":"en","type":"article","venue":"Immunity","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":259,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Medical Research Council; Mitacs; Cancer Research UK","keywords":"Biology; Major histocompatibility complex; Receptor; Antigen; T-cell receptor; Peptide; Cell; T cell; Cell biology; MHC restriction; Immunology; Virology; MHC class I; Immune system; Genetics; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0004698822,0.0002671023,0.000377371,0.0001442573,0.0002675483,0.0000116832,0.0005237095,0.0004859432,0.01209245],"category_scores_gemma":[0.00007259531,0.0002496214,0.0001390625,0.0001391597,0.0004116727,0.0000783131,0.0001647043,0.001149981,0.01138083],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002261671,"about_ca_system_score_gemma":0.0000882407,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007464415,"about_ca_topic_score_gemma":0.00006937407,"domain_scores_codex":[0.9983482,0.0003684586,0.0004679702,0.0003169925,0.00005971979,0.0004386287],"domain_scores_gemma":[0.9984971,0.0002721749,0.0003092883,0.0007192185,0.0001714818,0.00003070609],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002336111,0.0008061102,0.0003410398,0.00002419107,0.00005669515,0.000002397466,0.0002805412,7.489959e-7,0.9903187,0.00003521391,0.003645175,0.004255558],"study_design_scores_gemma":[0.001434837,0.0005593173,0.0008988862,0.00002796798,0.0000309196,0.00001560551,0.00017191,0.000001579766,0.9563965,0.000119837,0.04007801,0.0002645786],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9578203,0.0003509622,0.00001394475,0.00008711223,0.001245737,0.0002842218,0.00009568487,0.00008612713,0.0400159],"genre_scores_gemma":[0.9871103,0.0001980102,0.000258167,0.0001325939,0.0000310884,0.00001728099,0.0004657658,0.00002396964,0.01176287],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03643284,"threshold_uncertainty_score":0.9999956,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01297440794480603,"score_gpt":0.2180309725363854,"score_spread":0.2050565645915794,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}