{"id":"W1976672229","doi":"10.1016/j.jaci.2014.12.1930","title":"Inherited CARD9 deficiency in otherwise healthy children and adults with Candida species–induced meningoencephalitis, colitis, or both","year":2015,"lang":"en","type":"article","venue":"Journal of Allergy and Clinical Immunology","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":219,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine","funders":"National Center for Research Resources; National Institutes of Health; Astellas Pharma; Institut National de la Santé et de la Recherche Médicale; National Center for Advancing Translational Sciences; Agence Nationale de la Recherche; Cliniques Universitaires Saint-Luc; Regeneron Pharmaceuticals; ViiV Healthcare; Université Paris Descartes; Biogen; St. Giles Foundation; GlaxoSmithKline; Pfizer; Université de Montpellier; Gilead Sciences; Sanofi","keywords":"Meningoencephalitis; Candida albicans; Colitis; Biology; Candida glabrata; Immunology; Gastrointestinal tract; Medicine; Microbiology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008437978,0.000147072,0.0007004383,0.0000922957,0.00005081121,0.00001421007,0.00009484513,0.0002199458,0.00005886425],"category_scores_gemma":[0.000497308,0.00009457341,0.00006521438,0.0001609162,0.0004375678,0.0001023965,0.00004081797,0.0006149356,0.000001327954],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007489421,"about_ca_system_score_gemma":0.0006496696,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006928228,"about_ca_topic_score_gemma":0.006598378,"domain_scores_codex":[0.9981321,0.0002486784,0.0008661481,0.0002529394,0.0002062654,0.0002938872],"domain_scores_gemma":[0.9987891,0.00020943,0.0003334974,0.0001725113,0.0002060174,0.0002893873],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0624699,0.0009276677,0.9219328,0.00003297502,0.0006263874,0.0006586582,0.001327985,9.383039e-7,0.0001659444,0.0003525917,0.0006204713,0.01088375],"study_design_scores_gemma":[0.009614798,0.01000694,0.9762502,0.0002429357,0.00004257413,0.0009649224,0.001708441,0.000006382818,0.00001285031,0.00006974518,0.0009727504,0.0001074689],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933686,0.004765241,0.00001805176,0.001150521,0.0001385271,0.000172017,0.000005744995,0.000007344311,0.0003739639],"genre_scores_gemma":[0.9914472,0.007383357,0.0003032811,0.0005076568,0.0001218025,0.000001579497,0.000004030625,0.00001175499,0.000219387],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05431746,"threshold_uncertainty_score":0.3856592,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04094366111904613,"score_gpt":0.3335405676423736,"score_spread":0.2925969065233275,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}