{"id":"W1976689914","doi":"10.1074/jbc.m201187200","title":"Impaired Receptor Binding and Activation Associated with a Human Prostacyclin Receptor Polymorphism","year":2002,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Prostacyclin; Receptor; Internal medicine; Endocrinology; Platelet activation; Agonist; Biology; Chemistry; Pharmacology; Medicine; Platelet","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003604217,0.0001465321,0.0003597438,0.0000384518,0.00009416541,0.00001670718,0.00005621881,0.0002462649,0.0006442021],"category_scores_gemma":[0.0006553569,0.00008707448,0.00008150284,0.0001235274,0.0001140049,0.00006980389,0.00001760437,0.0004015605,0.000006908415],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001220444,"about_ca_system_score_gemma":0.00002526043,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":7.591725e-7,"about_ca_topic_score_gemma":6.839826e-8,"domain_scores_codex":[0.9990559,0.00004540035,0.0003483874,0.0001408112,0.0002101249,0.000199428],"domain_scores_gemma":[0.9990346,0.0001184256,0.000436378,0.0000801717,0.0001187122,0.0002117365],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002576805,0.0001660079,0.0437371,0.00004136044,0.00007622478,0.00004148901,0.00008587307,1.202252e-7,0.9533179,9.769485e-7,0.001555247,0.0007200352],"study_design_scores_gemma":[0.003900845,0.001779887,0.03555251,0.0007895063,0.00006904259,0.0002581474,0.000136565,0.00002631008,0.9559186,0.00001136524,0.001326143,0.0002311461],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989011,0.0001531144,0.000004330058,0.0004571485,0.00004677874,0.0001193244,0.000005507408,0.00002557318,0.0002870939],"genre_scores_gemma":[0.9987977,0.00006166028,0.0001644843,0.00008770308,0.0004267403,0.00000381504,0.00002386946,0.00001168599,0.0004223727],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008184587,"threshold_uncertainty_score":0.7053561,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02855715668073509,"score_gpt":0.2502508584941952,"score_spread":0.2216937018134601,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}