{"id":"W1976694517","doi":"10.1038/clpt.2011.174","title":"Plasma Letrozole Concentrations in Postmenopausal Women With Breast Cancer Are Associated With CYP2A6 Genetic Variants, Body Mass Index, and Age","year":2011,"lang":"en","type":"article","venue":"Clinical Pharmacology & Therapeutics","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":108,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Center for Research Resources; National Institute of General Medical Sciences; Canadian Institutes of Health Research; Novartis Pharma; Pfizer; Johns Hopkins University; National Institute on Drug Abuse; AstraZeneca; National Institutes of Health","keywords":"Letrozole; CYP2A6; Medicine; Breast cancer; Exemestane; Pharmacogenomics; Pharmacogenetics; Internal medicine; Body mass index; Pharmacology; Oncology; Aromatase inhibitor; Endocrinology; Aromatase; Genotype; Cancer; Biology; Genetics; Metabolism","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004528383,0.0001703137,0.0003911986,0.0003130904,0.0001449968,0.0002952954,0.0001084039,0.0004083258,0.0009504742],"category_scores_gemma":[0.002056108,0.0002386211,0.0002006384,0.0003838986,0.0001641803,0.0001951325,0.000141674,0.0003402454,0.0001813216],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001049307,"about_ca_system_score_gemma":0.00008405766,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003910362,"about_ca_topic_score_gemma":0.0006675934,"domain_scores_codex":[0.9997734,0.00009236334,0.00001760321,0.00003692549,0.00005777663,0.00002188629],"domain_scores_gemma":[0.9993765,0.0002360076,0.0002449354,0.00005379628,0.00002642992,0.00006230553],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0224194,0.0002975295,0.9318998,0.00005499634,0.0004433538,0.0004163708,0.0001523578,0.0002513839,0.02448745,0.00003682009,0.0002251979,0.01931529],"study_design_scores_gemma":[0.0003739649,0.001905585,0.9943908,0.00000358682,0.0001661197,0.0007652079,0.00003602811,0.0003045707,0.001618711,0.00006662291,0.0003634105,0.000005434754],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991149,0.0005020342,0.00007059654,0.00002503322,0.000003649465,0.000006820037,0.0000852618,0.000004732507,0.0001868808],"genre_scores_gemma":[0.999324,0.0001703734,0.0001095535,0.00002772493,0.00001127226,0.000008941163,0.0001317515,0.000001760954,0.0002145133],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009504742,"threshold_uncertainty_score":0.003179669,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02334594151501695,"score_gpt":0.3057416044835733,"score_spread":0.2823956629685563,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}