{"id":"W1976739454","doi":"10.1038/gene.2011.54","title":"Genetic diversity in human erythrocyte pyruvate kinase","year":2011,"lang":"en","type":"article","venue":"Genes and Immunity","topic":"Erythrocyte Function and Pathophysiology","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto General Hospital; University of Toronto; McGill University","funders":"Canadian Institutes of Health Research","keywords":"Biology; Pyruvate kinase deficiency; Haplotype; Genetic diversity; Malaria; Pyruvate kinase; Plasmodium falciparum; Genetics; Allele; Genetic variation; Natural selection; Nucleotide diversity; Gene; Single-nucleotide polymorphism; Selection (genetic algorithm); Genotype; Population; Immunology; Glycolysis; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000839729,0.0000936549,0.0001816025,0.00007520505,0.0002406066,0.000003275024,0.00005494393,0.00007319173,0.0004000601],"category_scores_gemma":[0.000008570588,0.00008373342,0.0000400579,0.00009121456,0.0001048058,0.000036997,0.0002268377,0.0001536372,0.00002226545],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001760899,"about_ca_system_score_gemma":0.00001555598,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002698481,"about_ca_topic_score_gemma":0.0001753372,"domain_scores_codex":[0.9994669,0.00006006956,0.000124351,0.0001395487,0.0000522097,0.0001569327],"domain_scores_gemma":[0.9996258,0.000009721038,0.00003286251,0.0002227614,0.00003358253,0.00007528735],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006051217,0.0004567713,0.7154757,0.0001344016,0.00005587805,0.0001386975,0.003852299,0.00000181768,0.2539746,0.0003373704,0.0002663797,0.02470091],"study_design_scores_gemma":[0.001047672,0.0003802661,0.9893681,0.00001852877,0.00002821732,0.00002104371,0.0003667823,0.00002298187,0.006999737,0.0004163825,0.001234398,0.00009590915],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957912,0.0008709903,0.00003687698,0.00002626173,0.0001182116,0.0001092466,0.000002542568,0.00002778036,0.003016905],"genre_scores_gemma":[0.9981277,0.0007625119,0.0003226113,0.0003519088,0.00004471542,0.000003266256,0.000009919602,0.000006727872,0.000370636],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2738923,"threshold_uncertainty_score":0.4380378,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05872866818034099,"score_gpt":0.2602385097426134,"score_spread":0.2015098415622724,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}