{"id":"W1976764606","doi":"10.1088/0957-4484/24/5/055101","title":"Synthesis and evaluation of diethylethylamine–chitosan for gene delivery: composition effects on the<i>in vitro</i>transfection efficiency","year":2013,"lang":"en","type":"article","venue":"Nanotechnology","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital du Sacré-Cœur de Montréal; Université de Montréal","funders":"Canadian Institutes of Health Research","keywords":"Chitosan; Transfection; HeLa; Lysozyme; Gene delivery; Zeta potential; In vitro; Cytotoxicity; Materials science; Nanoparticle; Surface charge; Dynamic light scattering; Biophysics; Molecular biology; Nuclear chemistry; Nanotechnology; Chemistry; Gene; Biochemistry; Biology; Physical chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005365443,0.0006265882,0.0003433617,0.0002910646,0.000199126,0.000332526,0.0002683334,0.000408509,0.0005517062],"category_scores_gemma":[0.0006771061,0.0002075082,0.0003772232,0.0003890412,0.0002067808,0.000286978,0.000161925,0.0002884488,0.0002466729],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005036629,"about_ca_system_score_gemma":0.0003041739,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002607822,"about_ca_topic_score_gemma":0.001907917,"domain_scores_codex":[0.999718,0.00005893685,0.00004385131,0.00005849376,0.00008074133,0.00004001254],"domain_scores_gemma":[0.9995276,0.0001155317,0.0001346152,0.00002991073,0.0001407708,0.00005168595],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000464878,0.000009935614,0.00004196443,0.00003179615,0.000002772364,0.00001250675,0.000006088348,0.00004669053,0.9991655,0.000008939678,0.000007153073,0.0006202831],"study_design_scores_gemma":[0.000002828553,0.00008499589,0.0003034351,0.000001446431,0.000008644878,0.00001638586,0.000002043226,0.0001810481,0.9991641,0.000002310313,0.0002296319,0.000002955262],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9814725,0.003626207,0.0122407,0.00009713588,0.0000484172,0.0001542086,0.0004075044,0.0001497443,0.001803562],"genre_scores_gemma":[0.9776304,0.003570298,0.01509264,0.00007980844,0.00002091587,0.0001313201,0.000637351,0.0001358372,0.002701477],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002607822,"threshold_uncertainty_score":0.005185306,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00957232484854426,"score_gpt":0.2353843587058088,"score_spread":0.2258120338572646,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}