{"id":"W1976794313","doi":"10.1186/s12864-015-1260-7","title":"Small RNAs derived from tRNAs and rRNAs are highly enriched in exosomes from both old and new world Leishmania providing evidence for conserved exosomal RNA Packaging","year":2015,"lang":"en","type":"article","venue":"BMC Genomics","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":158,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia Hospital; Simon Fraser University; University of British Columbia","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Conselho Nacional de Desenvolvimento Científico e Tecnológico","keywords":"RNA; Microvesicles; Biology; Non-coding RNA; Leishmania; Small RNA; Exosome complex; Exosome; Cell biology; Leishmania braziliensis; Molecular biology; microRNA; Gene; Genetics; Cutaneous leishmaniasis; Leishmaniasis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001393702,0.0002852062,0.0001693071,0.0006235506,0.0001830987,0.0003891926,0.0001226587,0.0002720654,0.001002716],"category_scores_gemma":[0.000363062,0.0001357342,0.0003516336,0.0002395395,0.0002451106,0.0002454944,0.0003289215,0.0002285542,0.0004897369],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000132171,"about_ca_system_score_gemma":0.00009465811,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000148763,"about_ca_topic_score_gemma":0.0002548582,"domain_scores_codex":[0.9998926,0.00001018405,0.00001221018,0.00003550947,0.00002524587,0.00002432999],"domain_scores_gemma":[0.9996561,0.00007378004,0.0001242546,0.00002992611,0.00006318191,0.00005279238],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001056328,0.000009616701,0.003028055,0.00007132313,0.0000171154,0.0002588071,0.00006632102,0.00001810085,0.9952074,0.00005964672,0.00002962667,0.00112848],"study_design_scores_gemma":[0.00004829839,0.0007458465,0.210242,0.00007923182,0.0001930788,0.007572083,0.0006203396,0.0009007065,0.7651619,0.000394489,0.01400638,0.00003559806],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915491,0.002400336,0.003437526,0.00007695614,0.00002803169,0.00002726377,0.00115378,0.00005514035,0.001271851],"genre_scores_gemma":[0.9933134,0.0007399216,0.002752543,0.0000686397,0.00002460757,0.00003036185,0.002044148,0.00003250753,0.0009939467],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001002716,"threshold_uncertainty_score":0.00335449,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2367484027667025,"score_gpt":0.3287071929218208,"score_spread":0.09195879015511832,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}