{"id":"W1976836673","doi":"10.1002/bit.24393","title":"Inhibition of glutamine‐dependent autophagy increases t‐PA production in CHO Cell fed‐batch processes","year":2011,"lang":"en","type":"article","venue":"Biotechnology and Bioengineering","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University; University of Manitoba; University of British Columbia; Canada's Michael Smith Genome Sciences Centre; University of British Columbia Hospital","funders":"","keywords":"Autophagy; Chinese hamster ovary cell; Glutamine; Recombinant DNA; Cell culture; Cell biology; Biochemistry; Fed-batch culture; Glycosylation; Chemistry; Biology; Apoptosis; Amino acid; Gene; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002468127,0.000422372,0.0005499594,0.0001736503,0.0001587391,0.0004990582,0.0002736718,0.0003266487,0.0003600212],"category_scores_gemma":[0.000238506,0.0001803636,0.0004455995,0.0002992044,0.0002043182,0.000298772,0.0002348443,0.0004674153,0.0003004224],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004916452,"about_ca_system_score_gemma":0.0003190217,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001315454,"about_ca_topic_score_gemma":0.002213641,"domain_scores_codex":[0.9998449,0.00002758879,0.0000238203,0.00003453875,0.00004815771,0.00002100751],"domain_scores_gemma":[0.9998454,0.00004233938,0.0000346369,0.00002384949,0.0000265752,0.00002708852],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007891841,0.00001436353,0.00009075453,0.00001958415,0.000004462108,0.00001911776,0.000006708538,0.00007287304,0.9991782,0.00001723949,0.00001685669,0.0004808993],"study_design_scores_gemma":[0.00000833744,0.0001278905,0.0008126801,0.000002326099,0.0000116199,0.00004146805,0.000006369887,0.0009201331,0.9975953,0.00001564754,0.0004537614,0.00000441779],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990263,0.001337564,0.006143128,0.00008972501,0.00003051613,0.00005691663,0.0007608337,0.0001652461,0.001152932],"genre_scores_gemma":[0.9764224,0.001220411,0.0180509,0.00006882245,0.00001345671,0.0001050544,0.001573236,0.00008203517,0.002463641],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001315454,"threshold_uncertainty_score":0.003567159,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008166939075342106,"score_gpt":0.2023595016511392,"score_spread":0.1941925625757971,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}