{"id":"W1976885903","doi":"10.1074/jbc.m101089200","title":"Protective Roles of NF-κB for Chromium(VI)-induced Cytotoxicity Is Revealed by Expression of IκB Kinase-β Mutant","year":2002,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"NF-κB Signaling Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute for Occupational Safety and Health; University of California, San Diego; Center for AIDS Research, University of Washington; Centers for Disease Control and Prevention; University of Ottawa","keywords":"IκB kinase; Programmed cell death; NF-κB; IκBα; Transfection; Kinase; Cell biology; Apoptosis; Caspase; Signal transduction; Transcription factor; Molecular biology; Biology; Chemistry; Gene; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009097877,0.0003735438,0.0001798257,0.0001314562,0.0001155862,0.0002482509,0.0001968595,0.0001576563,0.0009921447],"category_scores_gemma":[0.00008456416,0.0001210044,0.000203544,0.0001056828,0.0001995985,0.000152335,0.00009728735,0.0004504747,0.0003262902],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000282087,"about_ca_system_score_gemma":0.0002182187,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005465702,"about_ca_topic_score_gemma":0.0005854146,"domain_scores_codex":[0.9999239,0.000006625048,0.0000080118,0.00002371324,0.00001769808,0.00002011519],"domain_scores_gemma":[0.9999253,0.000006127544,0.00002814432,0.00001107918,0.000008817598,0.00002052274],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004351783,0.000006408487,0.00004002922,0.00001256674,0.000001182622,0.00001084275,0.000003188297,0.000009695797,0.9996734,0.00002870365,0.00000449661,0.0001660232],"study_design_scores_gemma":[0.0000107441,0.00009047136,0.001854954,0.000004553733,0.00001050478,0.000214604,0.00001375515,0.0002923032,0.9961576,0.00003889092,0.001309196,0.000002541929],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9851795,0.002896908,0.009569439,0.0001199746,0.00005057822,0.00002465148,0.0005292266,0.0001735179,0.001456219],"genre_scores_gemma":[0.9938216,0.001009199,0.002866109,0.0000254615,0.000005828326,0.00002351379,0.0005431895,0.00002837917,0.001676688],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009921447,"threshold_uncertainty_score":0.003319085,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03020156074975938,"score_gpt":0.2565573964016588,"score_spread":0.2263558356518994,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}