{"id":"W1976933067","doi":"10.1016/j.nmd.2006.05.255","title":"G.O. 8 Gene therapy trials in the ovine model of McArdle’s disease","year":2006,"lang":"en","type":"article","venue":"Neuromuscular Disorders","topic":"Glycogen Storage Diseases and Myoclonus","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Montreal Neurological Institute and Hospital; McGill University","funders":"","keywords":"Electroporation; Genetic enhancement; Plasmid; Gene isoform; Transduction (biophysics); Gene delivery; Transfection; Complementary DNA; Vector (molecular biology); Biology; Adeno-associated virus; Molecular biology; Medicine; Gene; Recombinant DNA; Genetics; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005488429,0.0005048073,0.0008797802,0.0005641599,0.0004136988,0.0006578799,0.0004997272,0.001940887,0.002616517],"category_scores_gemma":[0.0004693643,0.0001619916,0.0005743188,0.0002823946,0.0007769172,0.0006701812,0.0001618985,0.001288915,0.0004124858],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00037613,"about_ca_system_score_gemma":0.000494739,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009841017,"about_ca_topic_score_gemma":0.001275244,"domain_scores_codex":[0.9997658,0.00006596953,0.00001589723,0.0000540639,0.00003246922,0.00006591833],"domain_scores_gemma":[0.999786,0.00007210766,0.00003808165,0.00002900002,0.00001645043,0.0000584047],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.1150489,0.01338653,0.001471874,0.0008768964,0.0003422694,0.001500827,0.0005113012,0.001448143,0.7504129,0.003577719,0.004078255,0.1073445],"study_design_scores_gemma":[0.04903888,0.4414478,0.009045674,0.0002990437,0.0008215465,0.001714679,0.0004824239,0.003812263,0.4477658,0.002097958,0.0433637,0.0001103078],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899448,0.003781262,0.0007783028,0.001248316,0.0003261169,0.0001953937,0.0003001663,0.00009781166,0.003327938],"genre_scores_gemma":[0.9823337,0.003863882,0.002034441,0.0004878062,0.0001793562,0.000484476,0.0006788778,0.00003884039,0.009898629],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002616517,"threshold_uncertainty_score":0.008753121,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03701778653595499,"score_gpt":0.2843241467114984,"score_spread":0.2473063601755434,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}