{"id":"W1976962550","doi":"10.1074/jbc.m110.191411","title":"Recognition and Specificity Determinants of the Human Cbx Chromodomains","year":2010,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":310,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; University of Toronto; Structural Genomics Consortium","funders":"Knut och Alice Wallenbergs Stiftelse; Karolinska Institutet; Stiftelsen för Strategisk Forskning; Ontario Genomics Institute; Canadian Institutes of Health Research; Ontario Genomics; Genome Canada; Ontario Innovation Trust; Wellcome Trust; University of Toronto; GlaxoSmithKline","keywords":"Chromodomain; Heterochromatin protein 1; Biology; Genetics; Subfamily; Heterochromatin; Non-histone protein; Chromatin; Gene; Peptide sequence; Histone H3; DNA-binding protein; Histone; Function (biology); Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007765384,0.0001271487,0.00009994985,0.00009557227,0.00009637231,0.0001437362,0.000144224,0.0001336446,0.001315028],"category_scores_gemma":[0.0001811776,0.00009769425,0.0001090122,0.00006058313,0.0001468915,0.00007908561,0.0001168998,0.0002022623,0.0003106271],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002136426,"about_ca_system_score_gemma":0.0001340077,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009278228,"about_ca_topic_score_gemma":0.0010053,"domain_scores_codex":[0.9999156,0.00001168795,0.00000335393,0.00002618772,0.00002456355,0.00001859793],"domain_scores_gemma":[0.9998999,0.0000301923,0.00002239904,0.000009395549,0.00001007259,0.00002798174],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001072738,0.00001246837,0.001291951,0.00001627502,0.000004400502,0.00005925469,0.00002402559,0.0001604021,0.9965706,0.0001717584,0.0000321774,0.001549411],"study_design_scores_gemma":[0.00003139785,0.0002395723,0.05376683,0.00000884002,0.00001708033,0.0007672769,0.00005486886,0.003164233,0.9398948,0.0001904629,0.001854518,0.00001016782],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982591,0.0003102291,0.0007228285,0.00002207029,0.000002974001,0.000005588151,0.00004157427,0.0000109221,0.0006248166],"genre_scores_gemma":[0.9991691,0.00005291956,0.0003745546,0.00002047521,0.000001463476,0.000003549188,0.00004883857,0.000002269688,0.0003268444],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001315028,"threshold_uncertainty_score":0.00439918,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02214109120988935,"score_gpt":0.2468076493562544,"score_spread":0.224666558146365,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}