{"id":"W1976962550","doi":"10.1074/jbc.m110.191411","title":"Recognition and Specificity Determinants of the Human Cbx Chromodomains","year":2010,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":310,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; University of Toronto; Structural Genomics Consortium","funders":"Knut och Alice Wallenbergs Stiftelse; Karolinska Institutet; Stiftelsen för Strategisk Forskning; Ontario Genomics Institute; Canadian Institutes of Health Research; Ontario Genomics; Genome Canada; Ontario Innovation Trust; Wellcome Trust; University of Toronto; GlaxoSmithKline","keywords":"Chromodomain; Heterochromatin protein 1; Biology; Genetics; Subfamily; Heterochromatin; Non-histone protein; Chromatin; Gene; Peptide sequence; Histone H3; DNA-binding protein; Histone; Function (biology); Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001956869,0.00008290312,0.0001433789,0.000006093909,0.00005190652,0.000009006542,0.0002022524,0.0001982038,0.00003487377],"category_scores_gemma":[0.0001186142,0.00005037774,0.0001062407,0.00002577533,0.0001916548,0.0000017013,0.0001013612,0.0001982085,3.46912e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004934176,"about_ca_system_score_gemma":0.00002601192,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001350206,"about_ca_topic_score_gemma":0.000004703481,"domain_scores_codex":[0.999433,0.00001822107,0.0002838206,0.000103844,0.00006738447,0.00009373908],"domain_scores_gemma":[0.9993654,0.000011283,0.0003343069,0.0001482103,0.00008828692,0.00005250021],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001548496,0.00004823221,0.01931428,0.00001454839,0.00001059707,0.000002011542,0.000006333657,5.60551e-7,0.979395,0.000001907518,0.00002979693,0.001161244],"study_design_scores_gemma":[0.000267619,0.0001120756,0.04658806,0.00001415024,0.00001033271,0.0002416106,0.00003080042,0.000009228877,0.9515154,0.0006732284,0.0004640217,0.00007347831],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993966,0.0000859541,0.00001307759,0.0000240713,0.00007989895,0.00003206723,0.00002374327,0.000001066754,0.0003434688],"genre_scores_gemma":[0.999137,0.0001143893,0.0004352076,0.00002393086,0.0002420375,5.588565e-7,0.000007966883,0.000004748618,0.00003411717],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02787961,"threshold_uncertainty_score":0.2054344,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02214109120988935,"score_gpt":0.2468076493562544,"score_spread":0.224666558146365,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}