{"id":"W1976967080","doi":"10.3109/00498254.2010.529178","title":"The effect of increased lipoprotein levels on the pharmacokinetics of ketoconazole enantiomers in the rat","year":2010,"lang":"en","type":"article","venue":"Xenobiotica","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Ketoconazole; Pharmacokinetics; Pharmacology; Enantiomer; Lipoprotein; Medicine; Endocrinology; Biology; Internal medicine; Chemistry; Cholesterol; Antifungal; Microbiology; Stereochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002764118,0.0005046873,0.0004262453,0.0005030466,0.0001936948,0.0004603158,0.0002172275,0.0004467496,0.001172484],"category_scores_gemma":[0.0002725504,0.0003455873,0.0003727462,0.0002676775,0.0004379606,0.0004900168,0.0002061416,0.001236412,0.0004178341],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005515802,"about_ca_system_score_gemma":0.0004392651,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001526447,"about_ca_topic_score_gemma":0.001656254,"domain_scores_codex":[0.9997438,0.00005746873,0.00002062961,0.00006466061,0.00004683095,0.00006660979],"domain_scores_gemma":[0.999594,0.00005052263,0.0001355651,0.00006493807,0.0000397727,0.0001151027],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01148219,0.0007169187,0.001519895,0.00005935481,0.00004012759,0.0001752564,0.00005464961,0.0001459235,0.975663,0.0001611046,0.0001732057,0.009808397],"study_design_scores_gemma":[0.0002662924,0.008559205,0.01310958,0.000007894482,0.0001166765,0.0002617587,0.00007699589,0.001095228,0.9747332,0.0001092929,0.001635181,0.0000285782],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963947,0.0009730601,0.001287709,0.0001570749,0.00005062877,0.00002256358,0.0002894009,0.0001118627,0.0007129938],"genre_scores_gemma":[0.9944106,0.001197053,0.001616512,0.0001620652,0.00003222032,0.00005174237,0.0004040816,0.00003487401,0.002090919],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001526447,"threshold_uncertainty_score":0.004002035,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05158699698607702,"score_gpt":0.397180062483188,"score_spread":0.345593065497111,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}