{"id":"W1976967080","doi":"10.3109/00498254.2010.529178","title":"The effect of increased lipoprotein levels on the pharmacokinetics of ketoconazole enantiomers in the rat","year":2010,"lang":"en","type":"article","venue":"Xenobiotica","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Ketoconazole; Pharmacokinetics; Pharmacology; Enantiomer; Lipoprotein; Medicine; Endocrinology; Biology; Internal medicine; Chemistry; Cholesterol; Antifungal; Microbiology; Stereochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003747504,0.0002815959,0.0003573019,0.0001005224,0.0003113755,0.00002492206,0.001146547,0.0002303573,0.000500868],"category_scores_gemma":[0.0005248988,0.0001309493,0.0001834885,0.0004638032,0.0008847181,0.00003115006,0.0001173421,0.001598976,0.0000456789],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001098376,"about_ca_system_score_gemma":0.00008405907,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004971969,"about_ca_topic_score_gemma":0.0000336182,"domain_scores_codex":[0.9964747,0.001855179,0.0005655911,0.0002474204,0.0003642554,0.0004928234],"domain_scores_gemma":[0.9938578,0.005114128,0.0002796969,0.0005482112,0.00009101424,0.0001091678],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000659248,0.0002279042,0.00190492,0.0000526783,0.0001349772,0.00000834371,0.0004201168,0.0001217866,0.9682037,0.005383512,0.002133619,0.02074915],"study_design_scores_gemma":[0.002113754,0.0002265691,0.005251051,0.00001366258,0.000196749,0.000007799364,0.00006887229,0.000817597,0.8608471,0.0003120788,0.1300021,0.0001427547],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9862537,0.0005098815,0.00000509138,0.002943584,0.001409801,0.001616939,0.00009202135,0.00001578768,0.007153196],"genre_scores_gemma":[0.9978477,0.0002425266,0.00002060038,0.00136639,0.0002508516,0.0001068295,0.00000480771,0.00002476621,0.0001354877],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1278684,"threshold_uncertainty_score":0.6946842,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05158699698607702,"score_gpt":0.397180062483188,"score_spread":0.345593065497111,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}