{"id":"W1977011079","doi":"10.1016/j.freeradbiomed.2010.11.016","title":"Reduced DNA oxidation in aged prostaglandin H synthase-1 knockout mice","year":2010,"lang":"en","type":"article","venue":"Free Radical Biology and Medicine","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Neurodegeneration; DNA oxidation; Oxidative stress; Chemistry; DNA damage; Deoxyguanosine; Knockout mouse; Oxidative phosphorylation; Prostaglandin D2; Reactive oxygen species; Biochemistry; 8-Hydroxy-2'-deoxyguanosine; Prostaglandin; Internal medicine; DNA; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002981556,0.000967449,0.000971503,0.001881668,0.0003280828,0.0005386565,0.0005114833,0.001122531,0.00619945],"category_scores_gemma":[0.0003687538,0.0007591904,0.0004611766,0.0004771029,0.0006489952,0.0006836737,0.0003965722,0.001253451,0.0008382789],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000413677,"about_ca_system_score_gemma":0.0003262006,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009629632,"about_ca_topic_score_gemma":0.0009420552,"domain_scores_codex":[0.9996146,0.00003894179,0.00004458915,0.0001549233,0.00007435193,0.00007261919],"domain_scores_gemma":[0.9987997,0.00006606599,0.0005611841,0.0000880232,0.0001092719,0.0003757077],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007521238,0.00007077453,0.0002978222,0.00004396636,0.00001738805,0.0001051497,0.00003508013,0.00003410488,0.9976879,0.0001014725,0.00004598184,0.0008081976],"study_design_scores_gemma":[0.0002515326,0.001821039,0.02675395,0.00005025966,0.0002654049,0.001578227,0.0002465121,0.0007644074,0.9642713,0.0005098346,0.00344339,0.00004413723],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915132,0.001695002,0.003889833,0.0002159738,0.0001414877,0.00002796856,0.001444045,0.0003208145,0.0007517715],"genre_scores_gemma":[0.9839352,0.001577944,0.002860393,0.0001642044,0.00006266899,0.00009470879,0.000998291,0.0001698331,0.01013683],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00619945,"threshold_uncertainty_score":0.0207392,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009923051566574213,"score_gpt":0.2833170295335375,"score_spread":0.2733939779669633,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}