{"id":"W1977033276","doi":"10.1139/o08-124","title":"Kinetics of human peptidylarginine deiminase 2 (hPAD2) — Reduction of Ca<sup>2+</sup> dependence by phospholipids and assessment of proposed inhibition by paclitaxel side chains","year":2008,"lang":"en","type":"article","venue":"Biochemistry and Cell Biology","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Biochemistry; Enzyme; Phosphatidylserine; Phosphatidylcholine; Citrullination; In vitro; Myelin; Active site; Enzyme kinetics; Arginine; Stereochemistry; Phospholipid; Biology; Central nervous system; Amino acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001247697,0.0001813848,0.0003695725,0.00004491967,0.00007557412,0.000001753401,0.00008542438,0.0003847468,0.0001080319],"category_scores_gemma":[0.0000359655,0.0001657837,0.00005569336,0.00006127077,0.001071475,0.00002672113,0.00007534096,0.0001935901,9.962498e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001922695,"about_ca_system_score_gemma":0.00004409724,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001318183,"about_ca_topic_score_gemma":6.315656e-7,"domain_scores_codex":[0.9988979,0.0001355417,0.0004441127,0.0002867578,0.00003037184,0.0002052917],"domain_scores_gemma":[0.9993343,0.00005407922,0.0002818378,0.0001987676,0.000103584,0.00002740761],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000284663,0.0003904137,0.0005761815,0.0001820847,0.00005207177,0.000001155588,0.0003144346,9.223111e-7,0.9965351,0.00004242953,0.001271291,0.0003492838],"study_design_scores_gemma":[0.001274559,0.001466766,0.0002613805,0.00004897187,0.00003672358,0.000109084,0.0008704826,0.00001052825,0.9947953,0.00001155738,0.0009677632,0.000146856],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921185,0.006606488,0.00005784781,0.00004765324,0.00004728933,0.0001337655,0.000273227,0.000009696564,0.0007055308],"genre_scores_gemma":[0.9962462,0.001214139,0.00009576348,0.00001503947,0.00001245389,0.00000727528,0.0006034067,0.000008730981,0.001797003],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005392349,"threshold_uncertainty_score":0.6760463,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009459758238621609,"score_gpt":0.2467205356640296,"score_spread":0.237260777425408,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}