{"id":"W1977033769","doi":"10.1074/jbc.m314090200","title":"G Protein-coupled Receptor Kinase 2 Regulator of G Protein Signaling Homology Domain Binds to Both Metabotropic Glutamate Receptor 1a and Gαq to Attenuate Signaling","year":2004,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"Robarts Clinical Trials; Western University","funders":"","keywords":"G protein-coupled receptor kinase; G protein-coupled receptor; Beta adrenergic receptor kinase; Regulator of G protein signaling; Biology; Metabotropic glutamate receptor 1; Heterotrimeric G protein; 5-HT5A receptor; Metabotropic glutamate receptor; Arrestin; G protein; Enzyme-linked receptor; Cell biology; Interleukin-13 receptor; Biochemistry; Metabotropic receptor; Signal transduction; Receptor; GTPase-activating protein; Agonist; Insulin-like growth factor 1 receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009366835,0.0004060894,0.0007753029,0.00009270881,0.0001232846,0.00004615803,0.0004591756,0.0005107411,0.0002688595],"category_scores_gemma":[0.0004182542,0.0003122943,0.0003007344,0.0002646822,0.0001439939,0.00001384561,0.0002302346,0.0003508283,0.000007366979],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007586337,"about_ca_system_score_gemma":0.0001720652,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009552066,"about_ca_topic_score_gemma":6.62983e-7,"domain_scores_codex":[0.9973868,0.0001287884,0.001043253,0.0005771274,0.0003246193,0.000539412],"domain_scores_gemma":[0.9981363,0.00002754793,0.0006694073,0.0003193834,0.0003427441,0.0005045702],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001121584,0.0001480855,0.00008052627,0.00009084701,0.0001320567,0.00002417238,0.00006711068,0.0004666374,0.9972407,0.00005809372,0.00003033221,0.0005398828],"study_design_scores_gemma":[0.001290588,0.002326463,0.00003743451,0.0003515596,0.00002833312,0.00006939251,0.0001702936,0.000003123465,0.992639,0.0005718509,0.00212287,0.0003891009],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919184,0.0009535705,0.005847279,0.0005580469,0.0001345978,0.0005164746,0.00003645773,0.00001494134,0.00002017503],"genre_scores_gemma":[0.9516483,0.00005401738,0.04725649,0.0001836804,0.0006234481,0.00004461988,0.00002266122,0.00003885883,0.0001279091],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04140921,"threshold_uncertainty_score":0.9999329,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01165008886091346,"score_gpt":0.2330122236121199,"score_spread":0.2213621347512065,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}