{"id":"W1977040622","doi":"10.1074/jbc.m110.217026","title":"A Phosphodiesterase 3B-based Signaling Complex Integrates Exchange Protein Activated by cAMP 1 and Phosphatidylinositol 3-Kinase Signals in Human Arterial Endothelial Cells","year":2011,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Canadian Institutes of Health Research","keywords":"Phosphatidylinositol; Phosphodiesterase; Cell biology; Protein kinase A; Kinase; Chemistry; Biochemistry; Biology; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001561651,0.0002236751,0.0001596985,0.0001867386,0.0002653484,0.000331872,0.0001403786,0.0002510833,0.0007813165],"category_scores_gemma":[0.0001077436,0.0002489983,0.0002999533,0.0001423657,0.000153808,0.0001666229,0.0002596732,0.0004118846,0.0004323522],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004886548,"about_ca_system_score_gemma":0.0002393094,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001593298,"about_ca_topic_score_gemma":0.001265325,"domain_scores_codex":[0.9998896,0.00001746295,0.000008634259,0.00003166339,0.00003082602,0.00002174095],"domain_scores_gemma":[0.9999567,0.000005387078,0.000009689928,0.000008595418,0.000005899758,0.00001373298],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000616594,0.00001236079,0.0001644039,0.00001286901,0.000004385748,0.00003703704,0.00001011922,0.00004067664,0.9990508,0.0001483819,0.00003197384,0.0004253037],"study_design_scores_gemma":[0.00004383851,0.0001405661,0.01873347,0.00000738285,0.0000254371,0.0005267402,0.0000329715,0.004814942,0.9707617,0.0001501932,0.004755715,0.000007080003],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895355,0.001437766,0.007283917,0.0001175646,0.00002967143,0.00003430869,0.0004556444,0.00006157609,0.001043983],"genre_scores_gemma":[0.990879,0.0006375099,0.005007511,0.00006943371,0.000007951694,0.00004854748,0.001129106,0.00001617059,0.002204773],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001593298,"threshold_uncertainty_score":0.003545463,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03068292268399914,"score_gpt":0.2463192126584079,"score_spread":0.2156362899744087,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}