{"id":"W1977041235","doi":"10.1002/bit.20306","title":"In situ extraction strategy affects benzophenanthridine alkaloid production fluxes in suspension cultures of <i>Eschscholtzia californica</i>","year":2004,"lang":"en","type":"article","venue":"Biotechnology and Bioengineering","topic":"Plant tissue culture and regeneration","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Polytechnique Montréal","funders":"","keywords":"Chromatography; Chemistry; Secondary metabolite; Suspension (topology); Metabolite; Extraction (chemistry); Alkaloid; Suspension culture; Sanguinarine; Bioreactor; Cell culture; Chemical engineering; Biochemistry; Organic chemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008758448,0.000115727,0.0001295176,0.0001162659,0.00002755767,0.00000522401,0.00005231725,0.0003839118,7.094189e-7],"category_scores_gemma":[0.0000343576,0.00009671939,0.00002018756,0.000154182,0.00005965575,0.00001411011,0.00002781989,0.0001459651,7.976817e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001747271,"about_ca_system_score_gemma":0.00002158219,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008517653,"about_ca_topic_score_gemma":0.002140624,"domain_scores_codex":[0.9994136,0.00001114239,0.0001473546,0.0002421279,0.00004279813,0.0001429911],"domain_scores_gemma":[0.9998087,0.000002478402,0.00004446539,0.0001091575,0.00001535738,0.00001987834],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003578141,0.00004974841,0.0002642142,0.00003710093,0.00000916379,0.00001012644,0.00001910955,0.004031284,0.9946073,0.0002727991,0.00007674855,0.0005866095],"study_design_scores_gemma":[0.0003873794,0.0001574464,0.00156733,0.00005515735,0.000006184344,0.00009612078,0.00005232334,0.00002983047,0.9955324,0.00003708237,0.001964471,0.000114287],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993145,0.005166196,0.0003300327,0.001037266,0.0001338625,0.0001459785,0.000003034765,0.00001954588,0.00001911261],"genre_scores_gemma":[0.9971579,0.002275251,0.0003671287,0.00001636466,0.00008232931,0.000007909231,0.00005363377,0.000007139692,0.0000323474],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004012925,"threshold_uncertainty_score":0.3944102,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006735709161335353,"score_gpt":0.2350557053081548,"score_spread":0.2283199961468195,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}