{"id":"W1977052110","doi":"10.1039/b915450g","title":"DIBAL-H mediated triple and quadruple debenzylations of perbenzylated cyclodextrins","year":2009,"lang":"en","type":"article","venue":"Organic & Biomolecular Chemistry","topic":"Drug Solubulity and Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Glycomics Centre; University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; University of Calgary","keywords":"Chemistry; Reagent; Regioselectivity; Cyclodextrin; Hydride; Medicinal chemistry; Hexane; Combinatorial chemistry; Tetra; Organic chemistry; Catalysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003820011,0.00023262,0.0003264,0.0000499117,0.0001930387,0.00001876472,0.0002218861,0.0004558882,0.001263784],"category_scores_gemma":[0.0002412597,0.0002424816,0.0001055815,0.0004291584,0.0001607611,0.00007229701,0.00005390849,0.0004337826,0.00005568118],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004773766,"about_ca_system_score_gemma":0.0001057907,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004067164,"about_ca_topic_score_gemma":0.000007506424,"domain_scores_codex":[0.9984933,0.0001703117,0.0004584206,0.0003605829,0.0001785203,0.0003389018],"domain_scores_gemma":[0.9989712,0.0001239477,0.0002303486,0.0003045682,0.0001136137,0.0002563834],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007936195,0.0002548039,0.001120423,0.00006819399,0.0001194817,0.0000281486,0.0004864399,0.000004656116,0.9959486,0.00003400322,0.0006051019,0.001250796],"study_design_scores_gemma":[0.001797237,0.00007577438,0.001981561,0.00002173606,0.0001816331,0.00006575289,0.0001826017,0.003348405,0.9817974,0.0001676159,0.01006562,0.0003146408],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987182,0.002594079,0.003661179,0.0005071626,0.0002091301,0.0002760326,0.0001661493,0.0001581349,0.005246124],"genre_scores_gemma":[0.9984115,0.000323223,0.00008387064,0.0002862075,0.0000719034,0.000004982396,0.0001380724,0.0000198389,0.0006603579],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01415117,"threshold_uncertainty_score":0.9996492,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03576866912846591,"score_gpt":0.3523472308472804,"score_spread":0.3165785617188144,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}