{"id":"W1977069728","doi":"10.1016/j.febslet.2014.10.029","title":"Secondary conformational conversion is involved in glycosaminoglycans‐mediated cellular uptake of the cationic cell‐penetrating peptide PACAP","year":2014,"lang":"en","type":"article","venue":"FEBS Letters","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de la Recherche Scientifique; PROTEO; Université du Québec à Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Internalization; Glycosaminoglycan; Chemistry; Peptide; Cell biology; Cationic polymerization; Cell-penetrating peptide; Cell; Biochemistry; Biophysics; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001586927,0.0001120512,0.0001042298,0.00004335789,0.0000549213,0.00001429551,0.0002283598,0.00009304142,0.00007728049],"category_scores_gemma":[0.00003259319,0.00009543926,0.00007729658,0.00008018763,0.00007518064,0.00001044747,0.00006302718,0.0001195537,0.00002179638],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001815092,"about_ca_system_score_gemma":0.00008465841,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007855517,"about_ca_topic_score_gemma":0.00006854396,"domain_scores_codex":[0.9991788,0.00005708213,0.000284103,0.0001772467,0.0001395627,0.000163257],"domain_scores_gemma":[0.9994916,0.00001907948,0.0001505581,0.0002529627,0.00005337852,0.00003246906],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002389185,0.00001507624,0.009755013,0.00003259157,0.00001212796,3.984722e-7,0.0002232838,0.00009179036,0.9808911,0.00001008011,0.008769448,0.0001752036],"study_design_scores_gemma":[0.000775955,0.00008611465,0.0339227,0.00003301378,0.000009285694,0.0000013608,0.0002464468,0.000841267,0.9529616,0.00001238708,0.01095916,0.0001507448],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975616,0.00007981697,0.0002694838,0.0007897565,0.0001620635,0.0001244216,0.00002664397,0.000004014201,0.0009822435],"genre_scores_gemma":[0.9937412,0.00001969855,0.0001027094,0.005616366,0.00007188915,0.000007862242,0.0002789444,0.000008653933,0.0001526646],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02792953,"threshold_uncertainty_score":0.38919,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006761177113034177,"score_gpt":0.1917052655157925,"score_spread":0.1849440884027583,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}