{"id":"W1977079922","doi":"10.1006/abbi.2000.2115","title":"The Human Cytochrome P450 1A1 mRNA Is Rapidly Degraded In HepG2 Cells","year":2000,"lang":"en","type":"article","venue":"Archives of Biochemistry and Biophysics","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":63,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Medical Research Council Canada","keywords":"Messenger RNA; CYP1A2; Glyceraldehyde 3-phosphate dehydrogenase; Cytochrome P450; Biology; Molecular biology; P-bodies; Gene expression; Cell biology; Gene; Biochemistry; Enzyme; Translation (biology)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000171645,0.0002286314,0.000254815,0.00003275161,0.000287753,0.00002062014,0.0003711978,0.000135482,0.0002017626],"category_scores_gemma":[0.000005845438,0.0001825361,0.0001232867,0.0001571248,0.0007259585,0.00003462794,0.00008543037,0.000462087,0.00001416065],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006028911,"about_ca_system_score_gemma":0.00004297854,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001625532,"about_ca_topic_score_gemma":0.000001256831,"domain_scores_codex":[0.9987157,0.0001223087,0.0003503668,0.000311857,0.0001151547,0.0003846399],"domain_scores_gemma":[0.9991928,0.0002653995,0.0001108937,0.000249722,0.0000165186,0.0001647112],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001371136,0.0002153551,0.0002629068,0.0000580107,0.00007405569,0.000008092738,0.0005437893,0.00001315403,0.9269213,0.0001801602,0.0002911302,0.07129491],"study_design_scores_gemma":[0.001147397,0.00004022785,0.002911124,0.00001912944,0.00006059013,0.000005207999,0.00007044718,0.0004112348,0.9685732,0.003801362,0.02274654,0.0002135135],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9862726,0.002189212,0.000002062051,0.0004147547,0.00007797893,0.0001640688,0.0001291844,0.00001694163,0.01073323],"genre_scores_gemma":[0.9916102,0.005842013,0.0001098842,0.0005355178,0.0002160777,0.00001576706,0.0000207587,0.0000152357,0.001634584],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0710814,"threshold_uncertainty_score":0.7443604,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03520420764586936,"score_gpt":0.3557035254223258,"score_spread":0.3204993177764565,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}