{"id":"W1977092617","doi":"10.1002/cbic.201000144","title":"Influence of Cleavage Site on Global Folding of an RNA‐Cleaving DNAzyme","year":2010,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Deoxyribozyme; Cleavage (geology); Chemistry; Cleavage factor; RNA; Nucleic acid; Ribozyme; Nucleic acid structure; Biophysics; Protein folding; Folding (DSP implementation); Biochemistry; Stereochemistry; DNA; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001672651,0.0001611024,0.0002096868,0.00003367589,0.0000391922,0.000008239958,0.0002298033,0.0002177354,0.000001290099],"category_scores_gemma":[0.0001527885,0.0001507101,0.0001179542,0.0001609629,0.0001757377,0.000006704811,0.00009985999,0.0001206592,0.000001249293],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009959644,"about_ca_system_score_gemma":0.00002960925,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002330424,"about_ca_topic_score_gemma":0.00002620105,"domain_scores_codex":[0.9990354,0.00001711999,0.000265441,0.0003408323,0.0001510339,0.0001901531],"domain_scores_gemma":[0.9990105,0.00000867257,0.0002059652,0.0005643132,0.0001329305,0.00007759484],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006025857,0.00009015613,0.001484473,0.00002114053,0.00002461574,0.000001483515,0.00001224058,0.00001806108,0.9950967,0.0001026077,0.00006667253,0.00302153],"study_design_scores_gemma":[0.0001829885,0.000246529,0.003824097,0.00003355002,0.00002275236,0.00000742353,0.00002361354,0.0000271241,0.9950809,0.00009184293,0.0002938861,0.0001653183],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998498,0.00003625013,0.0000746951,0.00002296833,0.00002752764,0.00006783837,0.00003406002,0.00002888063,0.001209807],"genre_scores_gemma":[0.9952323,0.0000200882,0.004444888,0.00009463435,0.00009347096,0.000001913193,0.0000554621,0.00001402707,0.00004325865],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004370193,"threshold_uncertainty_score":0.6145778,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0049355215812377,"score_gpt":0.2696942039162828,"score_spread":0.2647586823350451,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}