{"id":"W1977092617","doi":"10.1002/cbic.201000144","title":"Influence of Cleavage Site on Global Folding of an RNA‐Cleaving DNAzyme","year":2010,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Deoxyribozyme; Cleavage (geology); Chemistry; Cleavage factor; RNA; Nucleic acid; Ribozyme; Nucleic acid structure; Biophysics; Protein folding; Folding (DSP implementation); Biochemistry; Stereochemistry; DNA; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004740825,0.0004889717,0.0005568182,0.00008195535,0.00009563608,0.0004940931,0.0002851888,0.0003331669,0.0005955362],"category_scores_gemma":[0.0006896059,0.0002030553,0.0002553843,0.000107731,0.0002800278,0.0002353653,0.0003092572,0.0006873132,0.0003220795],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002155993,"about_ca_system_score_gemma":0.000187804,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001976894,"about_ca_topic_score_gemma":0.0003308298,"domain_scores_codex":[0.9995908,0.00009186223,0.00004070721,0.0001279004,0.00009330165,0.00005534475],"domain_scores_gemma":[0.9995645,0.0001789173,0.0000954193,0.00004781932,0.00005000765,0.00006327531],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003822004,0.00001047992,0.0002477361,0.00001979144,0.000006099201,0.00002818333,0.00001355696,0.000150678,0.9987135,0.0000229438,0.000004156843,0.00074461],"study_design_scores_gemma":[0.000002449183,0.0001337622,0.0007907093,0.000002782067,0.000006967266,0.00006107491,0.00000962277,0.000662791,0.9980602,0.00001034553,0.000256395,0.000002773174],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947806,0.0003805229,0.004119567,0.00002152143,0.00001023833,0.00001778354,0.00005266934,0.00003545524,0.0005816828],"genre_scores_gemma":[0.9948612,0.0001902636,0.004237013,0.00002458263,0.000001889326,0.00002003145,0.0001158829,0.00002776816,0.0005213956],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005955362,"threshold_uncertainty_score":0.00250721,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0049355215812377,"score_gpt":0.2696942039162828,"score_spread":0.2647586823350451,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}