{"id":"W1977093051","doi":"10.1073/pnas.1303738110","title":"<i>Neisseria gonorrhoeae-</i> derived heptose elicits an innate immune response and drives HIV-1 expression","year":2013,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada; Child and Family Research Institute; University of British Columbia; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Neisseria gonorrhoeae; Heptose; Biology; Innate immune system; Microbiology; Lipid A; Bacterial outer membrane; Pathogen-associated molecular pattern; Gonorrhea; Escherichia coli; Mutant; Bacteria; Immune system; Gene; Virology; Biochemistry; Genetics; Human immunodeficiency virus (HIV)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001293541,0.000115495,0.0001761664,0.0001876132,0.0003365797,0.00003072913,0.0005312934,0.0001579255,0.00007426579],"category_scores_gemma":[0.0005688738,0.00007603032,0.00004789749,0.0003061403,0.0009110344,0.001080041,0.0001790667,0.0001734482,0.00002085832],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001504053,"about_ca_system_score_gemma":0.00003190864,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001022986,"about_ca_topic_score_gemma":2.136634e-8,"domain_scores_codex":[0.9990612,0.00006570506,0.0003796175,0.0002196777,0.00009431581,0.0001795444],"domain_scores_gemma":[0.9991091,0.0001822496,0.000415726,0.00001493787,0.0002611582,0.00001683597],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002714684,0.0000309692,0.0008951292,0.00001608686,0.00001220776,1.032561e-9,0.0006440892,0.000004556709,0.9950797,0.002132161,0.0002493981,0.0006642236],"study_design_scores_gemma":[0.0002819612,0.00008154588,0.2291825,0.00007266252,0.000005454542,0.00001229347,0.0004323362,0.00005493694,0.7667395,0.002623275,0.0004416126,0.00007190846],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961801,0.0007295973,7.964578e-7,0.002231616,0.00002964559,0.0002355343,0.000004484917,0.00001799765,0.000570221],"genre_scores_gemma":[0.9989594,0.00008555041,0.0003236649,0.0001359229,0.00001434091,0.00002242384,9.591408e-7,0.000004717528,0.0004530651],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2283402,"threshold_uncertainty_score":0.3356744,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01713791280844043,"score_gpt":0.2659853138901835,"score_spread":0.2488474010817431,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}