{"id":"W1977093051","doi":"10.1073/pnas.1303738110","title":"<i>Neisseria gonorrhoeae-</i> derived heptose elicits an innate immune response and drives HIV-1 expression","year":2013,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada; Child and Family Research Institute; University of British Columbia; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Neisseria gonorrhoeae; Heptose; Biology; Innate immune system; Microbiology; Lipid A; Bacterial outer membrane; Pathogen-associated molecular pattern; Gonorrhea; Escherichia coli; Mutant; Bacteria; Immune system; Gene; Virology; Biochemistry; Genetics; Human immunodeficiency virus (HIV)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006571081,0.0002104775,0.0001288792,0.00008273532,0.0001056352,0.0002674489,0.00008154016,0.0001879615,0.001106688],"category_scores_gemma":[0.00009756029,0.00006987617,0.0001337109,0.00008025773,0.0001385176,0.00008816619,0.0001783839,0.0002761703,0.0003435392],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003096531,"about_ca_system_score_gemma":0.0001507143,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008022254,"about_ca_topic_score_gemma":0.001173988,"domain_scores_codex":[0.9999127,0.00001346297,0.000005509877,0.00001688019,0.00002568928,0.00002569948],"domain_scores_gemma":[0.9999627,0.000005495678,0.00001162149,0.000004396274,0.000006191804,0.000009707819],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005243711,0.00001457287,0.0004251589,0.00002245071,0.000001991257,0.00004188481,0.000005801904,0.000021938,0.9981031,0.00007984861,0.00008348804,0.001147148],"study_design_scores_gemma":[0.00001354933,0.0004086799,0.01811013,0.00001483178,0.000009874281,0.0004311317,0.00006898138,0.000703243,0.9753676,0.0001348667,0.004732018,0.000005018154],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915847,0.001357462,0.001721445,0.0002227668,0.00003918822,0.00003499271,0.0005543215,0.00008066331,0.004404338],"genre_scores_gemma":[0.9947826,0.0005233511,0.001953962,0.0001588285,0.0000151286,0.00001726672,0.0005801808,0.000009548595,0.001959032],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001106688,"threshold_uncertainty_score":0.003702223,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01713791280844043,"score_gpt":0.2659853138901835,"score_spread":0.2488474010817431,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}