{"id":"W1977097370","doi":"10.1021/bm800132n","title":"Further Investigation of Lipid-Substituted Poly(<scp>l</scp>-Lysine) Polymers for Transfection of Human Skin Fibroblasts","year":2008,"lang":"en","type":"article","venue":"Biomacromolecules","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Transfection; Chemistry; Lysine; Polymer; Fibroblast; Biochemistry; Lower critical solution temperature; Polymer chemistry; Organic chemistry; In vitro; Amino acid; Copolymer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001715022,0.0002479439,0.0001054078,0.00008045911,0.00007369921,0.000157043,0.00007012816,0.0001998592,0.00045001],"category_scores_gemma":[0.0002115573,0.00006292813,0.0001673472,0.00009359066,0.00009296863,0.0001766168,0.0000688107,0.0001395802,0.0001688959],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001396646,"about_ca_system_score_gemma":0.0001708658,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003062854,"about_ca_topic_score_gemma":0.0003863716,"domain_scores_codex":[0.9999429,0.00001635944,0.0000075579,0.000009992005,0.00001377323,0.00000943459],"domain_scores_gemma":[0.9998827,0.00003859492,0.00003503704,0.000008215318,0.0000202311,0.0000151349],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000339564,0.0000102397,0.00009928149,0.00002629898,0.000001853903,0.00004097069,0.000006954493,0.00009382515,0.998639,0.00002025809,0.000004770309,0.001022601],"study_design_scores_gemma":[0.00000708992,0.0002794208,0.000870476,0.000003565083,0.000009138457,0.0001356249,0.000007047625,0.0003630249,0.9973541,0.000009207365,0.0009586677,0.000002566511],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941444,0.0008209344,0.00409362,0.00004200376,0.00001016753,0.00003617706,0.00006872904,0.00002224918,0.0007617546],"genre_scores_gemma":[0.992379,0.0007969681,0.005843577,0.00003358908,0.000004869877,0.00003395165,0.0001177668,0.000013164,0.0007772682],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00045001,"threshold_uncertainty_score":0.001505435,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01678345665978048,"score_gpt":0.2432519708714135,"score_spread":0.226468514211633,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}